Targeting lipid metabolism in regulatory T cells for enhancing cancer immunotherapy

被引：2
作者：
Yang, Liu [1 ,2 ,3 ,4 ]
Wang, Xingyue [2 ]
Wang, Shurong [1 ]
Shen, Jing [2 ,3 ,4 ]
Li, Yaling [1 ]
Wan, Shengli [1 ]
Xiao, Zhangang [2 ,3 ,4 ]
Wu, Zhigui [1 ,2 ,3 ,4 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Pharm, 25 Taiping Rd, Luzhou 646000, Sichuan, Peoples R China
[2] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, 1 Xianglin Rd, Luzhou 646000, Sichuan, Peoples R China
[3] South Sichuan Inst Translat Med, Luzhou 646000, Sichuan, Peoples R China
[4] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Personalised Cell Therapy & Cell Med, Luzhou 646000, Sichuan, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2025年 / 1880卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Regulatory T cells; Tumor microenvironment; Tumor immune evasion; Lipid metabolism; Cancer immunotherapy; FATTY-ACID OXIDATION; ANTITUMOR IMMUNITY; SUPPRESSOR-CELLS; TREG CELLS; GROWTH; METFORMIN; SURVIVAL; ACTIVATION; SECRETION; MICROENVIRONMENT;
D O I：
10.1016/j.bbcan.2025.189259
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As immunosuppressive cells, Regulatory T cells (Tregs) exert their influence on tumor immune escape within the tumor microenvironment (TME) by effectively suppressing the activity of other immune cells, thereby significantly impeding the anti-tumor immune response. In recent years, the metabolic characteristics of Tregs have become a focus of research, especially the important role of lipid metabolism in maintaining the function of Tregs. Consequently, targeted interventions aimed at modulating lipid metabolism in Tregs have been recognized as an innovative and promising approach to enhance the effectiveness of tumor immunotherapy. This review presents a comprehensive overview of the pivotal role of lipid metabolism in regulating the function of Tregs, with a specific focus on targeting Tregs lipid metabolism as an innovative approach to augment anti-tumor immune responses. Furthermore, we discuss potential opportunities and challenges associated with this strategy, aiming to provide novel insights for enhancing the efficacy of cancer immunotherapy.
引用
收藏
页数：15
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