Recent Advances in Lipid Nanoparticles and Their Safety Concerns for mRNA Delivery

被引：8

作者：

Wang, Jialiang ^{[1
]}

Ding, Yaopeng ^{[1
]}

Chong, Kellie ^{[2
]}

Cui, Meng ^{[3
]}

Cao, Zeyu ^{[3
]}

Tang, Chenjue ^{[1
]}

Tian, Zhen ^{[4
]}

Hu, Yuping ^{[2
]}

Zhao, Yu ^{[1
]}

Jiang, Shaoyi ^{[1
]}

机构：

[1] Cornell Univ, Meinig Sch Biomed Engn, Ithaca, NY 14853 USA

[2] Cornell Univ, Smith Sch Chem & Biomol Engn, Ithaca, NY 14853 USA

[3] Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA

[4] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA

来源：

VACCINES | 2024年 / 12卷 / 10期

关键词：

lipid nanoparticle; selective organ-targeting LNP; endosomal escape; toxicity; reactogenicity; immunogenicity; ACCELERATED BLOOD CLEARANCE; CHOLESTEROL CONTENT; SIRNA DELIVERY; IN-VIVO; LIPOSOMES; CELLS; THERAPEUTICS; EXPRESSION; VACCINES; IMPACT;

D O I：

10.3390/vaccines12101148

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: The advent of lipid nanoparticles (LNPs) as a delivery platform for mRNA therapeutics has revolutionized the biomedical field, particularly in treating infectious diseases, cancer, genetic disorders, and metabolic diseases. Recent Advances in Therapeutic LNPs: LNPs, composed of ionizable lipids, phospholipids, cholesterol, and polyethylene glycol (PEG) lipids, facilitate efficient cellular uptake and cytosolic release of mRNA while mitigating degradation by nucleases. However, as synthetic entities, LNPs face challenges that alter their therapeutic efficacy and safety concerns. Toxicity/Reactogenicity/Immunogenicity: This review provides a comprehensive overview of the latest advancements in LNP research, focusing on preclinical safety assessments encompassing toxicity, reactogenicity, and immunogenicity. Summary and Outlook: Additionally, it outlines potential strategies for addressing these challenges and offers insights into future research directions for enhancing the application of LNPs in mRNA therapeutics.

引用

页数：20

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