Recent Advances in Lipid Nanoparticles and Their Safety Concerns for mRNA Delivery

被引：7
|
作者：
Wang, Jialiang [1 ]
Ding, Yaopeng [1 ]
Chong, Kellie [2 ]
Cui, Meng [3 ]
Cao, Zeyu [3 ]
Tang, Chenjue [1 ]
Tian, Zhen [4 ]
Hu, Yuping [2 ]
Zhao, Yu [1 ]
Jiang, Shaoyi [1 ]
机构：
[1] Cornell Univ, Meinig Sch Biomed Engn, Ithaca, NY 14853 USA
[2] Cornell Univ, Smith Sch Chem & Biomol Engn, Ithaca, NY 14853 USA
[3] Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA
[4] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA
来源：
VACCINES | 2024年 / 12卷 / 10期
关键词：
lipid nanoparticle; selective organ-targeting LNP; endosomal escape; toxicity; reactogenicity; immunogenicity; ACCELERATED BLOOD CLEARANCE; CHOLESTEROL CONTENT; SIRNA DELIVERY; IN-VIVO; LIPOSOMES; CELLS; THERAPEUTICS; EXPRESSION; VACCINES; IMPACT;
D O I：
10.3390/vaccines12101148
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Introduction: The advent of lipid nanoparticles (LNPs) as a delivery platform for mRNA therapeutics has revolutionized the biomedical field, particularly in treating infectious diseases, cancer, genetic disorders, and metabolic diseases. Recent Advances in Therapeutic LNPs: LNPs, composed of ionizable lipids, phospholipids, cholesterol, and polyethylene glycol (PEG) lipids, facilitate efficient cellular uptake and cytosolic release of mRNA while mitigating degradation by nucleases. However, as synthetic entities, LNPs face challenges that alter their therapeutic efficacy and safety concerns. Toxicity/Reactogenicity/Immunogenicity: This review provides a comprehensive overview of the latest advancements in LNP research, focusing on preclinical safety assessments encompassing toxicity, reactogenicity, and immunogenicity. Summary and Outlook: Additionally, it outlines potential strategies for addressing these challenges and offers insights into future research directions for enhancing the application of LNPs in mRNA therapeutics.
引用
收藏
页数：20
相关论文
共 50 条
  • [1] Recent Advances in Lipid Nanoparticles for Delivery of mRNA
    Yang, Lei
    Gong, Liming
    Wang, Ping
    Zhao, Xinghui
    Zhao, Feng
    Zhang, Zhijie
    Li, Yunfei
    Huang, Wei
    PHARMACEUTICS, 2022, 14 (12)
  • [2] Lipid nanoparticles for mRNA therapy: recent advances in targeted delivery
    Wei, Tuo
    Tao, Wei
    Cheng, Qiang
    LIFE MEDICINE, 2022, 1 (01): : 21 - 23
  • [3] Recent Advances in Site-Specific Lipid Nanoparticles for mRNA Delivery
    Xu, Xiao
    Xia, Tian
    ACS NANOSCIENCE AU, 2023, 3 (03): : 192 - 203
  • [4] Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics
    Mukai, Hidefumi
    Ogawa, Koki
    Kato, Naoya
    Kawakami, Shigeru
    DRUG METABOLISM AND PHARMACOKINETICS, 2022, 44
  • [5] Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines
    Swetha, K.
    Kotla, Niranjan G.
    Tunki, Lakshmi
    Jayaraj, Arya
    Bhargava, Suresh K.
    Hu, Haitao
    Bonam, Srinivasa Reddy
    Kurapati, Rajendra
    VACCINES, 2023, 11 (03)
  • [6] Lipid nanoparticles for mRNA delivery
    Xucheng Hou
    Tal Zaks
    Robert Langer
    Yizhou Dong
    Nature Reviews Materials, 2021, 6 : 1078 - 1094
  • [7] Lipid nanoparticles for mRNA delivery
    Hou, Xucheng
    Zaks, Tal
    Langer, Robert
    Dong, Yizhou
    NATURE REVIEWS MATERIALS, 2021, 6 (12) : 1078 - 1094
  • [8] Lipid nanoparticles:: recent advances
    Mueller, Rainer H.
    ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (06) : 375 - 376
  • [9] Recent advances in siRNA delivery mediated by lipid-based nanoparticles
    Yonezawa, Sei
    Koide, Hiroyuki
    Asai, Tomohiro
    ADVANCED DRUG DELIVERY REVIEWS, 2020, 154 : 64 - 78
  • [10] Recent Advances in Intranasal Delivery with Lipid Nanoparticles for Brain Targeting: A Review
    Sidhaye, Isha
    Karadagi, Ameet
    Harish, K. H.
    Meti, Vijaykumar
    Dasankoppa, Fatima Sanjeri
    Swamy, Agadi Hiremath Viswanatha
    JOURNAL OF YOUNG PHARMACISTS, 2025, 17 (01) : 54 - 61
12345