Causal relationship between mental disorders and abdominal aortic aneurysm: Insights from the genetic perspective

被引：0
作者：
Deng, Ming-Gang [1 ,2 ]
Chai, Chen [3 ]
Wang, Kai [4 ]
Zhao, Zhi-Hui [5 ]
Nie, Jia-Qi [6 ]
Liu, Fang [7 ,8 ]
Liang, Yuehui [7 ]
Liu, Jiewei [1 ,2 ]
机构：
[1] Wuhan Mental Hlth Ctr, Dept Psychiat, Wuhan 430012, Hubei, Peoples R China
[2] Wuhan Hosp Psychotherapy, Dept Psychiat, Wuhan 430012, Hubei, Peoples R China
[3] Wuhan Univ, Zhongnan Hosp, Emergency Ctr, Hubei Clin Res Ctr Emergency & Resuscitat, Wuhan 430071, Hubei, Peoples R China
[4] Wuhan Fourth Hosp, Dept Publ Hlth, Wuhan 430000, Hubei, Peoples R China
[5] Shanghai Jiao Tong Univ, Sch Nursing, Shanghai 200025, Peoples R China
[6] Xiaogan Municipal Ctr Dis Control & Prevent, Xiaogan 432000, Hubei, Peoples R China
[7] Wuhan Univ, Sch Publ Hlth, Wuhan 430071, Hubei, Peoples R China
[8] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Hubei, Peoples R China
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2025年 / 137卷
关键词：
Mental disorders; Abdominal aortic aneurysm; Mendelian randomization; Genetic association; SCHIZOPHRENIA; INFLAMMATION; DEPRESSION; ASSOCIATION;
D O I：
10.1016/j.pnpbp.2025.111277
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: This study aims to investigate the genetic link between mental disorders-depression, schizophrenia (SCZ), and bipolar disorder (BIP)-and abdominal aortic aneurysm (AAA). Methods: We first examined the genetic associations between AAA and mental disorders by analyzing global and local genetic correlations as well as shared genomic loci. Global genetic correlation was assessed using linkage disequilibrium score regression (LDSC) and the GeNetic cOVariance Analyzer (GNOVA), while local genetic correlation was analyzed using the SUPERGNOVA approach. To identify shared genetic variants, the pleiotropyinformed conditional and conjunctional false discovery rate (pleioFDR) method was applied. Subsequently, the univariate Mendelian Randomization (UMR) was employed to evaluate the causal relationship, complemented by multivariate MR (MVMR) to account for potential confounding biases. Additionally, mediation analysis was performed to determine whether known risk factors mediate the identified causal relationships. Results: Global correlations showed positive links between depression, SCZ, and AAA, but not BIP. Local analyses identified specific genomic regions of correlation. We found 26, 141, and 10 shared loci for AAA with depression, SCZ, and BIP, respectively. UMR indicated significant associations between genetically predicted depression (OR 1.270; 95 % CI 1.071-1.504; p = 0.006) and SCZ (OR 1.047; 95 % CI 1.010-1.084; p = 0.011) with AAA, but not BIP. These results were confirmed by MVMR analyses. Mediation analyses showed that smoking, hypertension, hyperlipidemia, and coronary atherosclerosis mediated the impact of depression on AAA while smoking mediated SCZ's impact. Conclusion: This study provides evidence that genetically predicted depression and SCZ are linked to an increased risk of AAA, mediated by traditional AAA risk factors.
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页数：10
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