Visible Light-Induced Divergent Deoxygenation/Hydroxymethylation of Pyridine N-Oxides

被引：1

作者：

Feng, Changhao ^{[1
]}

Guo, Hao ^{[1
]}

Ding, Aishun ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200438, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 03期

关键词：

C-H-ARYLATION; EFFICIENT DEOXYGENATION; HYDROXYMETHYLATION; SULFOXIDES; CONSTRUCTION; CATALYST; DRUGS; WATER; ACIDS;

D O I：

10.1021/acs.joc.4c02770

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study explores the deoxygenation of pyridine N-oxides and presents a one-step photoredox method for the direct synthesis of 2-hydroxymethylated pyridines from pyridine N-oxides. Mechanism studies elucidate the role of the catalyst and provide evidence of the possible electron transfer process and the formation of key radicals. A range of pyridine derivatives, particularly 2-hydroxymethyl-substituted pyridines, which may be difficult to obtain, can be synthesized in a single step.

引用

页码：1376 / 1387

页数：12

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