Visible Light-Induced Divergent Deoxygenation/Hydroxymethylation of Pyridine N-Oxides

被引：1
|
作者：
Feng, Changhao [1 ]
Guo, Hao [1 ]
Ding, Aishun [1 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200438, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 03期
关键词：
C-H-ARYLATION; EFFICIENT DEOXYGENATION; HYDROXYMETHYLATION; SULFOXIDES; CONSTRUCTION; CATALYST; DRUGS; WATER; ACIDS;
D O I：
10.1021/acs.joc.4c02770
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This study explores the deoxygenation of pyridine N-oxides and presents a one-step photoredox method for the direct synthesis of 2-hydroxymethylated pyridines from pyridine N-oxides. Mechanism studies elucidate the role of the catalyst and provide evidence of the possible electron transfer process and the formation of key radicals. A range of pyridine derivatives, particularly 2-hydroxymethyl-substituted pyridines, which may be difficult to obtain, can be synthesized in a single step.
引用
收藏
页码：1376 / 1387
页数：12
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