Effect of Double Microemulsion on the Aga/CMC/MoS2 Nano Composites for Drug Delivery: Green Synthesis and Physico-Chemical Characterization

In this work, the nanocarriers were synthesized utilizing the water/oil/water (W/O/W) emulsifying method to deliver Curcumin. A cutting-edge hydrogel nanocomposite, resulting from the fusion of Carboxymethyl cellulose (CMC), Agarose (Aga) and Molybdenum disulfide (MoS2), presents groundbreaking ph-responsive solutions for drug delivery, with a focus on the controlled release of Curcumin (Cur), a robust element demonstrating exceptional prowess in neutralizing malignant cells. Incorporating MoS2 into the CMC-modified Aga hydrogel introduces distinctive attributes that are amplified by the addition of Span 80 surfactant. This combination results in the creation of strong niosomal microemulsions, which helps Cur stay in the body longer. Adding hazelnut oil helps to make the microemulsion smaller without changing its round shape. FT-IR spectroscopy and XRD techniques were utilized in order to examine the microemulsions. Dynamic light scattering (DLS) tests showed that there are tiny particles in the nanocarriers. They are about 171.25 nm in size on average and have a PDI of 0.31. The round shape of the tiny particles was confirmed by looking at them with a special microscope called SEM. The zeta potential analysis showed that there is a positive charge on the surface, which is about 80.4 mV. Surprisingly, the drug was able to be loaded at 48% efficiency, with an entrapment efficiency of 86.75%, exceeding the previously reported values. Researchers tested how well Cur-loaded nanoparticles can kill cancer cells and also looked for any harmful effects on A549 and L929 cells. This discovery shows that using tiny carriers could be a good way to treat cancer.