Eco-friendly cellulose/TiO2-hydroxyapatite films for biomedical applications

被引:0
作者
Devesa, Susana [1 ]
Benzarti, Zohra [1 ,2 ]
Costa, Madalena [3 ]
Cavaleiro, Diogo [1 ]
Faia, Pedro [4 ]
Carvalho, Sandra [1 ]
机构
[1] Univ Coimbra, Dept Mech Engn, CEMMPRE, ARISE, Rua Luis Reis Santos, P-3030788 Coimbra, Portugal
[2] Univ Sfax, Fac Sci Sfax, Dept Phys, Lab Multifunct Mat & Applicat LaMMA, Soukra Rd km 3 5,BP 1171, Sfax 3000, Tunisia
[3] Univ Coimbra, Phys Dept, Rua Larga, P-3004516 Coimbra, Portugal
[4] Univ Coimbra, Elect & Comp Engn Dept, CEMMPRE, FCTUC, Polo 2, P-3030290 Coimbra, Portugal
关键词
Cellulose; Hydroxyapatite; Biocompatible flexible films; CELLULOSE NANOCRYSTALS; IMPEDANCE SPECTROSCOPY; TITANIUM-DIOXIDE; ARTIFICIAL HYDROXYAPATITE; THERMAL-STABILITY; COMPOSITE; ELECTRODEPOSITION; NANOPARTICLES; TRANSLUCENCY; PERFORMANCE;
D O I
10.1016/j.ijbiomac.2025.141717
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this work cellulose/TiO2 flexible films coated with hydroxyapatite, aiming the development of electro-active orthopaedic scaffolds, were produced, applying sustainable procedures. The TiO2 nanoparticles were incorporated into the cellulose, extracted from potato peel, and the films were fabricated by the casting method. The hydroxyapatite, synthesized by the sol-gel technique, was electrodeposited onto the cellulose/TiO2 films, at room temperature. The resulting samples underwent comprehensive characterization using various techniques, including XRD, Raman Spectroscopy, SEM, EDS, TGA, DSC, and Impedance Spectroscopy (performed in a frequency range from 2 kHz to 40 MHz). The XRD and Raman Spectroscopy analyses of the extracted cellulose are consistent with the cellulose I polymorph and the SEM/EDS study of the cellulose/TiO2 films showed that the TiO2 nanoparticles are well dispersed within the biopolymer matrix, despite some aggregation that minimally affected film morphology. The successful electrodeposition of hydroxyapatite is suggested by SEM/EDS and confirmed by Raman Spectroscopy. The impedance spectra indicate that the uncoated samples' electrical response is associated with grain boundary effects, while for the coated ones the bulk resistance is the main contributor, with the bulk resistance and capacitance values suggesting potential for biomedical applications, particularly as electro-active orthopaedic scaffolds.
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页数:13
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