Diagnostic Decision Point for IgE-Mediated Wheat Allergy in Children

被引：0

作者：

Hwang, Yoonha ^{[1
]}

Kim, Jihyun ^{[2
]}

Ahn, Kangmo ^{[2
]}

Jeong, Kyunguk ^{[3
]}

Lee, Sooyoung ^{[3
]}

Hong, Soo-Jong ^{[4
]}

Jeon, You Hoon ^{[5
]}

Kim, Yoon Hee ^{[6
]}

Shin, Meeyong ^{[7
]}

Song, Tae Won ^{[8
]}

Jung, Minyoung ^{[9
]}

Kim, Minji ^{[10
]}

Min, Taek Ki ^{[11
]}

Lee, Ji Young ^{[12
]}

Kim, Min Jung ^{[13
]}

Lee, Yong Ju ^{[13
]}

Lee, Jeongmin ^{[14
]}

Park, Young A. ^{[15
]}

Jang, Gwang Cheon ^{[16
]}

Ahn, Young Min ^{[17
]}

Lee, So-Yeon ^{[18
,19
]}

Kim, Jeong Hee ^{[20
]}

机构：

[1] Busan St Marys Hosp, Dept Pediat, Busan, South Korea

[2] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pediat, Seoul, South Korea

[3] Ajou Univ, Sch Med, Dept Pediat, Suwon, South Korea

[4] Univ Ulsan, Childhood Asthma & Atopy Ctr, Humidifier Disinfectant Hlth Ctr, Coll Med,Asan Med Ctr,Dept Pediat, Seoul, South Korea

[5] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Pediat, Hwaseong, South Korea

[6] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Pediat, Seoul, South Korea

[7] Soonchunhyang Univ, Bucheon Hosp, Sch Med, Dept Pediat, Bucheon, South Korea

[8] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Pediat, Goyang, South Korea

[9] Kosin Univ, Gospel Hosp, Coll Med, Dept Pediat, Busan, South Korea

[10] Chungnam Natl Univ, Sejong Hosp, Sch Med, Dept Pediat, Sejong, South Korea

[11] Soonchunhyang Univ, Seoul Hosp, Coll Med, Dept Pediat, Seoul, South Korea

[12] Hallym Univ, Chuncheon Sacred Heart Hosp, Sch Med, Dept Pediat, Chunchon, South Korea

[13] Yonsei Univ, Yongin Severance Hosp, Coll Med, Dept Pediat, Yongin, South Korea

[14] Yonsei Univ, Wonju Coll Med, Dept Pediat, Wonju, South Korea

[15] Ewah Womans Univ, Seoul Hosp, Coll Med, Dept Pediat, Seoul, South Korea

[16] Ilsan Hosp, Natl Hlth Insurance Serv, Dept Pediat, Goyang, South Korea

[17] Jangs Hosp, Dept Pediat, Seoul, South Korea

[18] PHI Digital Healthcare, Seoul, South Korea

[19] Yonsei Univ, Inst innovat Digital Healthcare, Seoul, South Korea

[20] Inha Univ, Inha Univ Hosp, Coll Med, Dept Pediat, 27 Inhang Ro, Incheon 22332, South Korea

来源：

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | 2024年 / 16卷 / 05期

关键词：

Demographic; diagnosis; food allergy; ingestion; wheat; specific IgE; OMEGA-5; GLIADIN; MAJOR ALLERGEN; ANTIBODIES; CHALLENGE; UTILITY;

D O I：

10.4168/aair.2024.16.5.555

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The diagnostic decision point can help diagnose food allergies while reducing the need for oral food challenge (OFC) tests. We performed a multicenter survey of children aged 0-7 years from January 1, 2018 to March 31, 2022. A total of 231 children were recruited from 18 institutions. Wheat allergy (WA) or non-wheat allergy (NWA) was determined on the basis of OFC results and symptoms. There were no differences in age, sex, family history of allergy or allergic comorbidities between the WA and NWA groups. According to receiver operating characteristic analysis for wheat-specific immunoglobulin E (IgE), the optimal cutoff value, positive decision point, and negative decision point were 10.2, 33.5, and 0.41 kU/L, respectively. For the omega-5 gliadin-specific IgE, their values were 0.69, 3.88, and 0.01 kU/L, respectively. This new diagnostic decision point may be used to diagnose WA in Korean children.

引用

页码：555 / 561

页数：7

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