Recent Advances on the Regulations of Organic Anion Transporters

被引：2

作者：

Yu, Zhou ^{[1
]}

You, Guofeng ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Pharmaceut, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA

来源：

PHARMACEUTICS | 2024年 / 16卷 / 11期

关键词：

drug transporter; organic anion transporter; regulation; post-translational modification; diseases; drug disposition; TISSUE-SPECIFIC EXPRESSION; DRUG TRANSPORTERS; RENAL-FAILURE; TRANSCRIPTIONAL REGULATION; HYPERURICEMIC NEPHROPATHY; HEPATOCELLULAR-CARCINOMA; CATION TRANSPORTERS; TOPOISOMERASE-I; SLC22; FAMILY; OAT1;

D O I：

10.3390/pharmaceutics16111355

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The organic anion transporter (OAT) family of over 10 members within the solute carrier (SLC) superfamily of membrane proteins plays critical roles in facilitating the flux of negatively charged molecules in and out of cell membranes. These anionic molecules include various endogenous and exogenous compounds such as signaling molecules, nutrients, metabolites, toxins, and drugs. Therefore, OATs actively contribute to the systemic homeostasis and efficacy of therapeutics. This article provides a brief overview on recent advances in the understanding of the regulatory mechanisms that control the expression and activity of OATs in both health and diseases.

引用

页数：23

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