Association of inflammation, oxidative stress, and deteriorated cognitive functions in patients after cardiac surgery

被引:0
|
作者
Sabolova, Gabriela [1 ]
Koan, Ladislav [2 ]
Rabajdova, Miroslava [1 ]
Rapcanova, Simona [3 ]
Vaskova, Janka [1 ]
机构
[1] Pavol Jozef Safarik Univ Kosice, Fac Med, Dept Med & Clin Biochem, Tr SNP 1, Kosice 04011, Slovakia
[2] East Slovak Inst Cardiovasc Dis, Clin Anaesthesiol & Intens Care Med, Kosice 04011, Slovakia
[3] Europainclinics, Kominarska 21-5, Bratislava 83104, Slovakia
关键词
Blood-brain barrier; cardiac surgery; cognitive disorder; inflammation; oxidative stress delirium; ROS; VEGF; ASYMPTOMATIC CAROTID STENOSIS; CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; POSTOPERATIVE DELIRIUM; ISCHEMIC-STROKE; CIRCULAR RNAS; NONCARDIAC SURGERY; EARLY EXPOSURE; RISK-FACTORS;
D O I
10.20517/2574-1209.2024.05
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The study is focused on the connection between cognitive dysfunction, inflammatory processes, oxidative stress, and various associated biological factors. Postoperative cognitive dysfunction is a condition where a patient exhibits a temporary deterioration in cognitive function after surgery, which may include problems with memory, concentration, and overall cognitive performance. While most common among elderly patients, it can occur in individuals of any age. The causes are not fully elucidated, but it is assumed that peripheral trauma during longterm surgical interventions is behind the development of inflammation and the creation of conditions of oxidative stress, which leads to the disruption of the blood-brain barrier and the subsequent development of cognitive impairment. This review aims to describe the detected changes at the level of selected markers of inflammation and oxidative damage in patients, primarily in connection with cardiac surgery.
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收藏
页数:25
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