Late Re-Engagement Into HIV Care Among Adults in the Swiss HIV Cohort Study

被引:0
|
作者
Haas, Andreas D. [1 ]
Kusejko, Katharina [2 ,3 ]
Cavassini, Matthias [4 ]
Gunthard, Huldrych [2 ,3 ]
Stockle, Marcel [5 ]
Calmy, Alexandra [6 ]
Bernasconi, Enos [7 ,8 ]
Schmid, Patrick [9 ]
Egger, Matthias [1 ,10 ,11 ]
Wandeler, Gilles [1 ,12 ]
Swiss HIV Cohort Study
机构
[1] Kantonsspital, Munsterlingen, Switzerland
[2] Univ Hosp Zurich, Dept Infect Dis & Hosp Epidemiol, Zurich, Switzerland
[3] Univ Zurich, Inst Med Virol, Zurich, Switzerland
[4] Univ Lausanne, Univ Hosp Lausanne, Munsterlingen, Switzerland
[5] Univ Hosp Basel, Div Infect Dis & Hosp Epidemiol, Basel, Switzerland
[6] Univ Geneva, Geneva Univ Hosp, Munsterlingen, Switzerland
[7] Kantonsspital, Ente Osped Cantonale Lugano, Div Infect Dis, Geneva, Switzerland
[8] Univ Southern Switzerland, Lugano, Switzerland
[9] Kantonsspital, St Gallen, Switzerland
[10] Univ South Africa, Florida, South Africa
[11] AND Engn & Assoc, Kolkata, England
[12] Univ Bern, Bern Univ Hosp, Munsterlingen, Switzerland
基金
瑞士国家科学基金会;
关键词
late re-engagement; advanced HIV disease; loss to follow-up; retention; ANTIRETROVIRAL THERAPY; RETENTION;
D O I
10.1097/QAI.0000000000003597
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction: Little is known about the clinical status of persons with HIV who re-engage in care after an interruption. We evaluated the immunologic and clinical characteristics of individuals re-engaging in care within the Swiss HIV Cohort Study. Methods: Participants who re-engaged in care after an interruption >14 months with a viral load >= 100 copies/mL were classified as having interrupted antiretroviral therapy (ART). We defined late re-engagement as re-engaging with a CD4 cell count of <350 cells/<mu>L or a new Centers for Disease Control and Prevention stage C disease. Linear and logistic regression models with restricted cubic splines were used to estimate the mean CD4 cell count at re-engagement and the probability of late re-engagement as a function of care interruption duration. Results: Of 14,864 participants with a median follow-up of 10.2 years (interquartile range 4.7-17.2 years), 2768 (18.6%) interrupted care, of whom 1489 (53.8%) re-engaged. Among those re-engaging, 62.3% had interrupted ART. For participants who interrupted ART, the mean CD4 count declined from 374 cells/mu L [95% confidence interval (CI): 358 to 391 cells/mu L] before the interruption to 250 cells/mu L (95% CI: 221 to 281 cells/mu L) among those re-engaging after 14 months, and to 185 cells/mu L (95% CI: 160 to 212 cells/mu L) among those re-engaging after 60 months. The estimated risk of late re-engagement in care was 68.6% (95% CI: 62.3% to 74.4%) for participants who interrupted ART for 14 months and 75.2% (95% CI: 68.9% to 80.6%) for those who interrupted ART for 60 months. Conclusions: Although HIV care interruptions are not very common in Switzerland, most persons with HIV re-engaging after interrupting ART return with late-stage HIV.
引用
收藏
页码:491 / 500
页数:10
相关论文
共 50 条
  • [21] Integrating a Resilience Framework to Assess Implementation of a Novel HIV Care Re-Engagement Model in NYC
    Baim-Lance, Abigail
    Addison, Diane
    Archer, Norman
    Gordon, Peter
    Duke, Sharen
    Shubert, Virginia
    Nash, Denis
    Robertson, Mckaylee
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2023, 94 (04) : 308 - 316
  • [22] Factors influencing the implementation of a guideline for re-engagement in HIV care in primary care settings in Johannesburg, South Africa: A qualitative study
    Makina-Zimalirana, Ndinda
    Wilkinson, Lynne Susan
    Grimsrud, Anna
    Davies, Natasha
    Mutyambizi, Chipo
    Jiyane, Anele
    Buthelezi, Fezile
    Rees, Kate
    PLOS GLOBAL PUBLIC HEALTH, 2024, 4 (10):
  • [23] Swiss HIV Cohort Study
    不详
    AIDS PATIENT CARE AND STDS, 1999, 13 (06) : 376 - 376
  • [24] HIV Testing and Re-engagement for Individuals with Previously Diagnosed HIV Infection in New Orleans, Louisiana
    Humphrey, John
    Hadi, Christiane M.
    Richey, Lauren E.
    AIDS PATIENT CARE AND STDS, 2012, 26 (09) : 509 - 511
  • [25] Access and engagement in HIV care among a national cohort of women living with HIV in Canada
    Kronfli, Nadine
    Lacombe-Duncan, Ashley
    Wang, Ying
    de Pokomandy, Alexandra
    Kaida, Angela
    Logie, Carmen
    Conway, Tracey
    Kennedy, V. Logan
    Burchell, Ann
    Tharao, Wangari
    Pick, Neora
    Kestler, Mary
    Sereda, Paul
    Loutfy, Mona
    AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2017, 29 (10): : 1235 - 1242
  • [26] An Exploratory Study to Assess Individual and Structural Level Barriers Associated With Poor Retention and Re-engagement in Care Among Persons Living With HIV/AIDS
    Colasanti, Jonathan
    Stahl, Natalie
    Farber, Eugene W.
    del Rio, Carlos
    Armstrong, Wendy S.
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2017, 74 : S113 - S120
  • [27] The Role of Patient-Provider Communication in Engagement and Re-engagement in HIV Treatment in Bamako, Mali: A Qualitative Study
    Hurley, Emily A.
    Harvey, Steven A.
    Winch, Peter J.
    Keita, Mariam
    Roter, Debra L.
    Doumbia, Seydou
    Diarra, Niele H.
    Kennedy, Caitlin E.
    JOURNAL OF HEALTH COMMUNICATION, 2018, 23 (02) : 129 - 143
  • [28] Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study
    Wolbers, M.
    Bucher, H. C.
    Furrer, H.
    Rickenbach, M.
    Cavassini, M.
    Weber, R.
    Schmid, P.
    Bernasconi, E.
    Hirschel, B.
    Battegay, M.
    HIV MEDICINE, 2008, 9 (06) : 397 - 405
  • [29] Cohort Profile: The Swiss HIV Cohort Study
    Schoeni-Affolter, Franziska
    Ledergerber, Bruno
    Rickenbach, Martin
    Rudin, Christoph
    Guenthard, Huldrych F.
    Telenti, Amalio
    Furrer, Hansjakob
    Yerly, Sabine
    Francioli, Patrick
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2010, 39 (05) : 1179 - 1189
  • [30] Prevalence of HIV-related stigma among participants of the Swiss HIV Cohort Study: a pilot study
    Kampouri, E.
    Damas, J.
    Jackson-Perry, D.
    Manuel, I. Cobos
    Scherrer, A.
    Cavassini, M.
    Darling, K.
    JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2020, 23 : 82 - 82