Cortisol Secretion in Obesity Revisited: Lower Basal Serum and Salivary Cortisol with Diminished Cortisol Response to the Low Dose ACTH Challenge

被引：0
作者：
Sofer, Yael [1 ,2 ]
Osher, Esther [1 ,2 ]
Abu Ahmad, Wiessam [3 ]
Greenman, Yona [1 ,2 ]
Moshe, Yaffa [1 ]
Shaklai, Sigal [1 ,2 ]
Yaron, Marianna [1 ]
Serebro, Merav [1 ,2 ]
Tordjman, Karen [1 ,2 ]
Stern, Naftali [1 ,2 ]
机构：
[1] Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, Tel Aviv, Israel
[2] Tel Aviv Univ, Fac Med, Tel Aviv, Israel
[3] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Braun Sch Publ Hlth & Community Med, Jerusalem, Israel
来源：
OBESITY FACTS | 2025年
关键词：
Cortisol; Serum free cortisol; Obesity; Low dose ACTH test; PITUITARY-ADRENAL AXIS; 1; MU-G; ABDOMINAL OBESITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; FAT DISTRIBUTION; WOMEN; STIMULATION; STRESS; MEN;
D O I：
10.1159/000543449
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction:Some clinical resemblance may exist betweenobesity, particularly abdominal obesity, and Cushing's syn-drome. This has stimulated ongoing interest in the role ofcortisol's secretion pattern, control, and metabolism inobesity.Goals:The aim of the study was to investigatewhether basal and stimulated levels of cortisol differ be-tween healthy people with obesity and individuals withnormal weight.Methods:Total, free, and salivary cortisolwas tested at baseline state and after 1 mu g ACTH stimulationin 60 healthy subjects with obesity and 54 healthy leancontrols.Results:Baseline total cortisol was lower in subjectswith obesity compared to lean controls (347 [265-452]nmol/L vs. 422 [328-493] nmol/L, respectively;p<0.05).Similarly, basal salivary cortisol was significantly lower insubjects with obesity (7.5 [5.2-9.7] nmol/L vs. 10.7 [7.5-17.6]nmol/L;p<0.05). Upon challenge with ACTH, total peakserum and salivary peak cortisol responses were significantlylower in people with obesity than in lean subjects (665.16 +/- 151.8 vs. 728.64 +/- 124.2 nmol/L;p<0.05 and 31.66[19-38.64] vs. 40.05 [31.46-46.64] nmol/L;p<0.05, re-spectively). Additionally, baseline total cortisol and salivarycortisol were inversely related to BMI (r=-0.24,r=-0.27;p<0.05 for both) and waist circumference (r=-0.27,r=-0.34;p<0.05 for both).Conclusion:Baseline as well as peakstimulated total serum and salivary cortisol were signifi-cantly lower in subjects with obesity. It thus appears thatobesity is not associated with enhanced basal or ACTH-stimulated cortisol.(c) 2025 The Author(s).Published by S. Karger AG, Basel
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页数：9
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