Cortisol Secretion in Obesity Revisited: Lower Basal Serum and Salivary Cortisol with Diminished Cortisol Response to the Low Dose ACTH Challenge

被引:0
作者
Sofer, Yael [1 ,2 ]
Osher, Esther [1 ,2 ]
Abu Ahmad, Wiessam [3 ]
Greenman, Yona [1 ,2 ]
Moshe, Yaffa [1 ]
Shaklai, Sigal [1 ,2 ]
Yaron, Marianna [1 ]
Serebro, Merav [1 ,2 ]
Tordjman, Karen [1 ,2 ]
Stern, Naftali [1 ,2 ]
机构
[1] Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, Tel Aviv, Israel
[2] Tel Aviv Univ, Fac Med, Tel Aviv, Israel
[3] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Braun Sch Publ Hlth & Community Med, Jerusalem, Israel
关键词
Cortisol; Serum free cortisol; Obesity; Low dose ACTH test; PITUITARY-ADRENAL AXIS; 1; MU-G; ABDOMINAL OBESITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; FAT DISTRIBUTION; WOMEN; STIMULATION; STRESS; MEN;
D O I
10.1159/000543449
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction:Some clinical resemblance may exist betweenobesity, particularly abdominal obesity, and Cushing's syn-drome. This has stimulated ongoing interest in the role ofcortisol's secretion pattern, control, and metabolism inobesity.Goals:The aim of the study was to investigatewhether basal and stimulated levels of cortisol differ be-tween healthy people with obesity and individuals withnormal weight.Methods:Total, free, and salivary cortisolwas tested at baseline state and after 1 mu g ACTH stimulationin 60 healthy subjects with obesity and 54 healthy leancontrols.Results:Baseline total cortisol was lower in subjectswith obesity compared to lean controls (347 [265-452]nmol/L vs. 422 [328-493] nmol/L, respectively;p<0.05).Similarly, basal salivary cortisol was significantly lower insubjects with obesity (7.5 [5.2-9.7] nmol/L vs. 10.7 [7.5-17.6]nmol/L;p<0.05). Upon challenge with ACTH, total peakserum and salivary peak cortisol responses were significantlylower in people with obesity than in lean subjects (665.16 +/- 151.8 vs. 728.64 +/- 124.2 nmol/L;p<0.05 and 31.66[19-38.64] vs. 40.05 [31.46-46.64] nmol/L;p<0.05, re-spectively). Additionally, baseline total cortisol and salivarycortisol were inversely related to BMI (r=-0.24,r=-0.27;p<0.05 for both) and waist circumference (r=-0.27,r=-0.34;p<0.05 for both).Conclusion:Baseline as well as peakstimulated total serum and salivary cortisol were signifi-cantly lower in subjects with obesity. It thus appears thatobesity is not associated with enhanced basal or ACTH-stimulated cortisol.(c) 2025 The Author(s).Published by S. Karger AG, Basel
引用
收藏
页数:9
相关论文
共 44 条
  • [1] Scaroni C., Albiger N.M., Palmieri S., Iacuaniello D., Graziadio C., Damiani L., Et al., Approach to patients with pseudo-Cushing's states, Endocr Connect., 9, 1, pp. R1-R13, (2020)
  • [2] Marin P., Darin N., Amemiya T., Andersson B., Jern S., Bjorntorp P., Cortisol secretion in relation to body fat distribution in obese premenopausal women, Metabolism., 41, 8, pp. 882-886, (1992)
  • [3] Stewart P.M., Boulton A., Kumar S., Clark P.M., Ch S., Cortisol metabolism in human obesity: Impaired cortisone->cortisol conversion in subjects with central adiposity, J Clin Endocrinol Metab., 84, 3, pp. 1022-1027, (1999)
  • [4] Andrew R., Phillips D.I., Walker B.R., Obesity and gender influence cortisol secretion and metabolism in man, J Clin Endocrinol Metab., 83, 5, pp. 1806-1809, (1998)
  • [5] Bjorntorp P., Rosmond R., Obesity and cortisol, Nutrition., 16, 10, pp. 924-936, (2000)
  • [6] Bose M., Olivan B., Laferrere B., Stress and obesity: The role of the hypothalamicpituitary-adrenal axis in metabolic disease, Curr Opin Endocrinol Diabetes Obes., 16, 5, pp. 340-346, (2009)
  • [7] Lucassen E.A., Cizza G., The hypothalamicpituitary-adrenal Axis, obesity, and chronic stress exposure: Sleep and the HPA Axis in obesity, Curr Obes Rep., 1, 4, pp. 208-215, (2012)
  • [8] Rosmond R., Dallman M.F., Bjorntorp P., Stress-related cortisol secretion in men: Relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities, J Clin Endocrinol Metab., 83, 6, pp. 1853-1859, (1998)
  • [9] Vicennati V., Pasquali R., Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: Evidence for a central and a peripheral alteration, J Clin Endocrinol Metab., 85, 11, pp. 4093-4098, (2000)
  • [10] Pasquali R., Cantobelli S., Casimirri F., Capelli M., Bortoluzzi L., Flamia R., Et al., The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution, J Clin Endocrinol Metab., 77, 2, pp. 341-346, (1993)