D-Penicillamine-Induced Stevens-Johnson Syndrome in a Patient with Gold Cyanide Intoxication: A Case Report

被引：0

作者：

Anuntrangsee, Tanaporn ^{[1
]}

Chanprapaph, Kumutnart ^{[1
]}

Iamsumang, Wimolsiri ^{[1
]}

机构：

[1] Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Dermatol,Dept Med, 270 Rama VI Rd, Bangkok 10400, Thailand

来源：

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY | 2024年 / 17卷

关键词：

chelating agent; cutaneous adverse drug reaction; cyanide; epidermal necrolysis; gold salt; penicillamine; TOXIC EPIDERMAL NECROLYSIS; CELLS;

D O I：

10.2147/CCID.S489028

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

D-penicillamine is used as the mainstay of chelation therapy for Wilson's disease and for heavy metal intoxication. D-penicillamine itself has been noted to cause several systemic side effects as well as symptoms related to the skin. Common cutaneous side effects such as acute hypersensitivity reactions, elastic fiber abnormalities, and bullous diseases have been occasionally described. Herein, we report a case of a 23-year-old Thai female with gold intoxication who developed Stevens-Johnson syndrome (SJS) following the treatment of D-penicillamine. To our knowledge, D-penicillamine-induced SJS is exceptionally rare. To raise awareness of potentially fatal cutaneous adverse drug reaction triggered by D-penicillamine, published literature regarding SJS induced by this agent has also been reviewed. D-penicillamine should be regarded as a possible culprit in patients presenting with SJS following D-penicillamine administration and should be promptly discontinued.

引用

页码：2409 / 2415

页数：7

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