Clinical indications for host-cell DNA methylation markers in cervical screening and management of cervical intraepithelial neoplasia: A review

被引：0
作者：
Dick, S. [1 ,2 ]
Heideman, D. A. M. [1 ,2 ,4 ]
Berkhof, J. [2 ,3 ]
Steenbergen, R. D. M. [1 ,2 ]
Bleeker, M. C. G. [1 ,2 ]
机构：
[1] Locat Vrije Univ Amsterdam, Amsterdam UMC, Pathol, Boelelaan, NL-1117 Amsterdam, Netherlands
[2] Canc Ctr Amsterdam Imaging & Biomarkers, Amsterdam, Netherlands
[3] Locat Vrije Univ Amsterdam, Amsterdam UMC, Epidemiol & Data Sci, Amsterdam, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Hanzepl 1, NL-9713GZ Groningen, Netherlands
来源：
TUMOUR VIRUS RESEARCH | 2025年 / 19卷
关键词：
DNA methylation; Cervical cancer; Cervical screening; Human papillomavirus; Cervical intraepithelial neoplasia; Triage test; Conservative treatment; Management of CIN; Post-treatment monitoring; Host-cell DNA methylation; HIGH-RISK HPV; HRHPV POSITIVE WOMEN; LONG-TERM RISK; GRADE; CADM1/MAL METHYLATION; SELF-SAMPLES; TRIAGE TEST; FOLLOW-UP; IN-SITU; CANCER;
D O I：
10.1016/j.tvr.2024.200308
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
DNA methylation of host-cell genes is an epigenetic process that regulates gene expression and is associated with cervical cancer development. Studies on the natural history of cervical intraepithelial neoplasia (CIN) and the molecular alterations associated with cervical carcinogenesis led to the identification of several host-cell DNA methylation markers. Over the past years, various studies on methylation markers have shown promising results in terms of diagnostic and prognostic value to improve cervical cancer screening and management of CIN. This review provides an overview of the clinical indications of host-cell DNA methylation markers in cervical screening and management of CIN, and outlines avenues for further applications.
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页数：9
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