Uremic Toxins Elimination from Simulated Intestinal Serum with Mesoporous Silica Nanoparticles Coupled with Molecularly Imprinted Polymers and Amino Linker

被引:0
作者
Miardan, Leila Nazmi [1 ]
Rezaii, Ebrahim [1 ]
Mahkam, Mehrdad [1 ]
Khosroshahi, Hamid Tayebi [2 ]
机构
[1] Azarbaijan Shahid Madani Univ, Fac Sci, Dept Chem, Tabriz, Iran
[2] Tabriz Univ Med Sci, Dept Nephrol, Tabriz, Iran
关键词
Renal failure; mesoporous silica nanoparticles; molecularly imprinted polymers; simulated serum; uremic toxins; chronic kidney disease; CREATININE; UREA; ADSORPTION; EXTRACTION; REMOVAL;
D O I
10.2174/0115701794282603240115112013
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Background One of the most researched issues is the elimination of uremic toxins from the human body. These toxins can build up and lead to catastrophic issues including renal failure. To get rid of them, absorbents like activated carbon, zeolites, and other minerals are frequently utilized.Methods Mesoporous silica nanoparticles functionalized with (3-Aminopropyl) triethoxysilane (APTES) linker (MSN-NH2) and mesoporous silica nanoparticles grafted with molecularly imprinted polymers (MSN-MIP) from the previous study were examined in this study to determine how well they absorbed urea, creatinine, and uric acid in a simulated intestinal serum.Results MSN-MIP's large surface area (879.12 (m2/g)) and volume of pores (0.8475 (cm3/g)) made removal results that were satisfactory in the simulated serum. Additionally, MSN-MIP demonstrated a high urea adsorption capacity (qm = 1836.45 mg/g). Creatinine (qm = 1529.5 mg/g) and uric acid (qm = 1210.6 mg/g) were absorbed via NH-MSN2, which demonstrated a noticeable potential for absorption. The results of cell viability test for the first 72 hours, showed that the use of these absorbents in hemodialysis systems is acceptable.Conclusion Synthesized adsorbents can be utilized in the hemodialysis system since the results of the cell viability test also showed that the percentage of cell viability was extremely high up to 72 hours.
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页码:243 / 252
页数:10
相关论文
共 33 条
  • [1] Molecularly imprinted polymer for the removal of diclofenac from water: Synthesis and characterization
    Abu Samah, Nurlin
    Sanchez-Martin, Maria-Jesus
    Ma Sebastian, Rosa
    Valiente, Manuel
    Lopez-Mesas, Montserrat
    [J]. SCIENCE OF THE TOTAL ENVIRONMENT, 2018, 631-632 : 1534 - 1543
  • [2] Molecularly Imprinted Polymers
    BelBruno, Joseph J.
    [J]. CHEMICAL REVIEWS, 2019, 119 (01) : 94 - 119
  • [3] Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
    Bikbov, Boris
    Purcell, Carrie
    Levey, Andrew S.
    Smith, Mari
    Abdoli, Amir
    Abebe, Molla
    Adebayo, Oladimeji M.
    Afarideh, Mohsen
    Agarwal, Sanjay Kumar
    Agudelo-Botero, Marcela
    Ahmadian, Elham
    Al-Aly, Ziyad
    Alipour, Vahid
    Almasi-Hashiani, Amir
    Al-Raddadi, Rajaa M.
    Alvis-Guzman, Nelson
    Amini, Saeed
    Andrei, Tudorel
    Andrei, Catalina Liliana
    Andualem, Zewudu
    Anjomshoa, Mina
    Arabloo, Jalal
    Ashagre, Alebachew Fasil
    Asmelash, Daniel
    Ataro, Zerihun
    Atout, Maha Moh'd Wahbi
    Ayanore, Martin Amogre
    Badawi, Alaa
    Bakhtiari, Ahad
    Ballew, Shoshana H.
    Balouchi, Abbas
    Banach, Maciej
    Barquera, Simon
    Basu, Sanjay
    Bayih, Mulat Tirfie
    Bedi, Neeraj
    Bello, Aminu K.
    Bensenor, Isabela M.
    Bijani, Ali
    Boloor, Archith
    Borzi, Antonio M.
    Camera, Luis Alberto
    Carrero, Juan J.
    Carvalho, Felix
    Castro, Franz
    Catala-Lopez, Ferran
    Chang, Alex R.
    Chin, Ken Lee
    Chung, Sheng-Chia
    Cirillo, Massimo
    [J]. LANCET, 2020, 395 (10225) : 709 - 733
  • [4] Nanoporous biomaterials for uremic toxin adsorption in artificial kidney systems: A review
    Cheah, Wee-Keat
    Ishikawa, Kunio
    Othman, Radzali
    Yeoh, Fei-Yee
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2017, 105 (05) : 1232 - 1240
  • [5] Clearance of low molecular-weight uremic toxins p-cresol, creatinine, and urea from simulated serum by adsorption
    Cheng, Yu-Chin
    Fu, Chun-Chieh
    Hsiao, Yu-Sheng
    Chien, Chu-Chun
    Juang, Ruey-Shin
    [J]. JOURNAL OF MOLECULAR LIQUIDS, 2018, 252 : 203 - 210
  • [6] Enhanced and selective adsorption of urea and creatinine on amine-functionalized mesoporous silica SBA-15 via hydrogen bonding
    Chi Hieu Nguyen
    Fu, Chun-Chieh
    Chen, Ze-Han
    Thi Tuong Van Tran
    Liu, Shou-Hsuan
    Juang, Ruey-Shin
    [J]. MICROPOROUS AND MESOPOROUS MATERIALS, 2021, 311
  • [7] MIP-based solid phase extraction cartridges combined with MIP-based sensors for the detection of microcystin-LR
    Chianella, I
    Piletsky, SA
    Tothill, IE
    Chen, B
    Turner, APF
    [J]. BIOSENSORS & BIOELECTRONICS, 2003, 18 (2-3) : 119 - 127
  • [8] Duan FF, 2016, ENVIRON SCI-NANO, V3, P213, DOI [10.1039/c5en00198f, 10.1039/C5EN00198F]
  • [9] Efficient and reversible absorption of HCl gas by ChCl-based deep eutectic solvents-Insights into the absorption behavior and mechanism
    Feng, Lin
    Meng, Hong
    Lu, Yingzhou
    Li, Chunxi
    [J]. SEPARATION AND PURIFICATION TECHNOLOGY, 2022, 281
  • [10] Foreman KJ, 2018, LANCET, V392, P2052, DOI [10.1016/S0140-6736(18)31694-5, 10.1016/s0140-6736(18)31694-5]