The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives

被引：1

作者：

de Souza, Cassia Milena ^{[1
]}

Bezerra, Barbara Tavares ^{[1
]}

Mellon, Daniel Agreda ^{[1
,2
]}

de Oliveira, Haroldo Cesar ^{[1
,3
]}

机构：

[1] Fundacao Oswaldo Cruz Fiocruz, Inst Carlos Chagas, Curitiba, PR, Brazil

[2] Fundacao Oswaldo Cruz Fiocruz, Programa Posgrad Biol Parasitaria, Inst Oswaldo Cruz, Rio De Janeiro, Brazil

[3] Fed Univ Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Discipline Cellular Biol, Sao Paulo, Brazil

来源：

CURRENT RESEARCH IN MICROBIAL SCIENCES | 2025年 / 8卷

关键词：

Antifungal therapy; Antifungal drugs; Antifungal drug development; IN-VITRO ACTIVITY; SEROTONIN REUPTAKE INHIBITORS; AMPHOTERICIN-B; FLUCONAZOLE RESISTANCE; COMBINATION THERAPY; SILVER NANOPARTICLES; REZAFUNGIN CD101; ASPERGILLUS SPP; DRUG-RESISTANCE; CANDIDA;

D O I：

10.1016/j.crmicr.2025.100341

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fungal infections kill more than 3 million people every year. This high number reflects the significant challenges that treating these diseases worldwide presents. The current arsenal of antifungal drugs is limited and often accompanied by high toxicity to patients, elevated treatment costs, increased frequency of resistance rates, and the emergence of naturally resistant species. These treatment challenges highlight the urgency of developing new antifungal therapies, which could positively impact millions of lives each year globally. Our review offers an overview of the antifungal drugs currently available for treatment, presents the status of new antifungal drugs under clinical study, and explores ahead to future candidates that aim to help address this important global health issue.

引用

页数：20

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