The Prognostic Values of Serum Liver Enzymes in Intrahepatic Cholangiocarcinoma Patients After Liver Resection: A Multi-Institutional Analysis of 605 Patients

被引:0
作者
Huang, Yang [1 ]
Liao, Anque [2 ]
Xu, Liangliang [1 ]
Li, Hui [3 ]
Xu, Mingqing [1 ]
Jiang, Li [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Gen Surg, Div Liver Surg, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, West China Sch Nursing, Dept Operat Room, Chengdu, Peoples R China
[3] Chongqing Univ, Canc Hosp, Dept Hepatobiliary Pancreat Tumor Ctr, Chongqing 400030, Peoples R China
来源
CANCER MANAGEMENT AND RESEARCH | 2024年 / 16卷
基金
中国国家自然科学基金;
关键词
liver enzyme; cholangiocarcinoma; hepatectomy; prognostic factor; nomogram; GAMMA-GLUTAMYL-TRANSPEPTIDASE; HEPATOCELLULAR-CARCINOMA; TRANSFERASE; INDEX; POPULATION; PREDICTION; SURVIVAL; MARKER; RISK;
D O I
10.2147/CMAR.S478477
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The value of liver enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), in predicting the prognosis of intrahepatic cholangiocarcinoma (ICC) patients who underwent curative resection has not been elucidated. Therefore, we aimed to construct prognostic nomograms for surgically treated ICC patients. Methods: The impact of liver enzymes on overall survival (OS) and recurrence-free survival (RFS) was analysed using Kaplan-Meier analysis and evaluated by univariate and multivariate analyses. Nomograms were constructed for predicting the probability of 1-, 3-, and 5-year OS and RFS and evaluated by receiver operating characteristic (ROC) curves, calibration curves and decision curve Results: High ALT, AST, ALP and GGT levels were associated with worse prognoses in surgically treated ICC patients. Nomograms for OS and RFS were constructed based on five prognostic factors: number of high liver enzyme (No. HLE), CA19-9 >= 37 U/mL, multiple tumours, lymph node invasion and microvascular invasion (MVI). Compared with 8th edition TNM stage, these nomograms showed better predictive value. The C-index and 1-, 3- and 5-year areas under the curve (AUCs) of the nomograms for OS and RFS in the discovery and validation cohorts were higher than those of the 8th TNM stage. The calibration plots indicated that there was good agreement between the actual observations and predictions. Conclusion: Preoperative ALT, AST, ALP and GGT levels could predict prognosis in surgically treated ICC patients. The nomograms showed good predictive ability for predicting the survival of ICC patients.
引用
收藏
页码:1649 / 1662
页数:14
相关论文
共 34 条
  • [1] Cholangiocarcinoma 2020: the next horizon in mechanisms and management
    Banales, Jesus M.
    Marin, Jose J. G.
    Lamarca, Angela
    Rodrigues, Pedro M.
    Khan, Shahid A.
    Roberts, Lewis R.
    Cardinale, Vincenzo
    Carpino, Guido
    Andersen, Jesper B.
    Braconi, Chiara
    Calvisi, Diego F.
    Perugorria, Maria J.
    Fabris, Luca
    Boulter, Luke
    Macias, Rocio I. R.
    Gaudio, Eugenio
    Alvaro, Domenico
    Gradilone, Sergio A.
    Strazzabosco, Mario
    Marzioni, Marco
    Coulouarn, Cedric
    Fouassier, Laura
    Raggi, Chiara
    Invernizzi, Pietro
    Mertens, Joachim C.
    Moncsek, Anja
    Rizvi, Sumera
    Heimbach, Julie
    Koerkamp, Bas Groot
    Bruix, Jordi
    Forner, Alejandro
    Bridgewater, John
    Valle, Juan W.
    Gores, Gregory J.
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020, 17 (09) : 557 - 588
  • [2] Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma
    Bridgewater, John
    Galle, Peter R.
    Khan, Shahid A.
    Llovet, Josep M.
    Park, Joong-Won
    Patel, Tushar
    Pawlik, Timothy M.
    Gores, Gregory J.
    [J]. JOURNAL OF HEPATOLOGY, 2014, 60 (06) : 1268 - 1289
  • [3] A Hepatocellular Carcinoma Aggressiveness Index and Its Relationship to Liver Enzyme Levels
    Carr, Brian I.
    Guerra, Vito
    [J]. ONCOLOGY, 2016, 90 (04) : 215 - 220
  • [4] Negative Impact of Preoperative Platelet-Lymphocyte Ratio on Outcome After Hepatic Resection for Intrahepatic Cholangiocarcinoma
    Chen, Qing
    Dai, Zhi
    Yin, Dan
    Yang, Liu-Xiao
    Wang, Zheng
    Xiao, Yong-Sheng
    Fan, Jia
    Zhou, Jian
    [J]. MEDICINE, 2015, 94 (13)
  • [5] Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription
    Chen, Qinjunjie
    Wang, Haibo
    Li, Zheng
    Li, Fengwei
    Liang, Leilei
    Zou, Yiran
    Shen, Hao
    Li, Jun
    Xia, Yong
    Cheng, Zhangjun
    Yang, Tian
    Wang, Kui
    Shen, Feng
    [J]. JOURNAL OF HEPATOLOGY, 2022, 76 (01) : 135 - 147
  • [6] Collins GS, 2015, ANN INTERN MED, V162, P55, DOI [10.1016/j.jclinepi.2014.11.010, 10.7326/M14-0697, 10.1186/s12916-014-0241-z, 10.1002/bjs.9736, 10.7326/M14-0698, 10.1038/bjc.2014.639, 10.1016/j.eururo.2014.11.025, 10.1136/bmj.g7594]
  • [7] Pretherapeutic gamma-glutamyltransferase is an independent prognostic factor for patients with renal cell carcinoma
    Hofbauer, S. L.
    Stangl, K. I.
    de Martino, M.
    Lucca, I.
    Haitel, A.
    Shariat, S. F.
    Klatte, T.
    [J]. BRITISH JOURNAL OF CANCER, 2014, 111 (08) : 1526 - 1531
  • [8] Serum aminotransferase level and the risk of hepatocellular carcinoma: a population-based cohort study in Japan
    Ishiguro, Seiji
    Inoue, Manami
    Tanaka, Yasuhito
    Mizokami, Masashi
    Iwasaki, Motoki
    Tsugane, Shoichiro
    [J]. EUROPEAN JOURNAL OF CANCER PREVENTION, 2009, 18 (01) : 26 - 32
  • [9] Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry
    Izquierdo-Sanchez, Laura
    Lamarca, Angela
    La Casta, Adelaida
    Buettner, Stefan
    Utpatel, Kirsten
    Klumpen, Heinz-Josef
    Adeva, Jorge
    Vogel, Arndt
    Lleo, Ana
    Fabris, Luca
    Ponz-Sarvise, Mariano
    Brustia, Raffaele
    Cardinale, Vincenzo
    Braconi, Chiara
    Vidili, Gianpaolo
    Jamieson, Nigel B.
    Macias, Rocio Ir
    Jonas, Jan Philipp
    Marzioni, Marco
    Holowko, Waclaw
    Folseraas, Trine
    Kupcinskas, Juozas
    Sparchez, Zeno
    Krawczyk, Marcin
    Krupa, Lukasz
    Scripcariu, Viorel
    Grazi, Gian Luca
    Landa-Magdalena, Ana
    Ijzermans, Jan Nm
    Evert, Katja
    Erdmann, Joris, I
    Lopez-Lopez, Flora
    Saborowski, Anna
    Scheiter, Alexander
    Santos-Laso, Alvaro
    Carpino, Guido
    Andersen, Jesper B.
    Marin, Jose Jg
    Alvaro, Domenico
    Bujanda, Luis
    Forner, Alejandro
    Valle, Juan W.
    Koerkamp, Bas Groot
    Banales, Jesus M.
    [J]. JOURNAL OF HEPATOLOGY, 2022, 76 (05) : 1109 - 1121
  • [10] Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease
    Kim, W. Ray
    Flamm, Steven L.
    Di Bisceglie, Adrian M.
    Bodenheimer, Henry C., Jr.
    [J]. HEPATOLOGY, 2008, 47 (04) : 1363 - 1370