Harnessing Bacterial Agents to Modulate the Tumor Microenvironment and Enhance Cancer Immunotherapy

被引:3
作者
Thomas, Christina James [1 ]
Delgado, Kaylee [1 ]
Sawant, Kamlesh [1 ]
Roy, Jacob [1 ]
Gupta, Udit [1 ]
Song, Carly Shaw [1 ]
Poojary, Rayansh [1 ]
de Figueiredo, Paul [2 ]
Song, Jianxun [1 ]
机构
[1] Texas A&M Univ, Hlth Sci Ctr, Dept Microbial Pathogenesis & Immunol, MREB 2,Room 3344,8447 John Sharp Pkwy, Bryan, TX 77807 USA
[2] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA
关键词
cancer immunotherapy; tumor microenvironment; engineered bacteria; immunosuppression; immune checkpoint inhibitors; bacterial therapeutics; antitumor immunity; ATTENUATED SALMONELLA-TYPHIMURIUM; METASTATIC BREAST-CANCER; ACTIVATION GENE-3 LAG-3; T-CELL DIFFERENTIATION; CLOSTRIDIUM-NOVYI-NT; SUPPRESSOR-CELLS; BACTERIOLYTIC THERAPY; DENDRITIC CELLS; IN-VITRO; HPV E7;
D O I
10.3390/cancers16223810
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer immunotherapy has revolutionized cancer treatment by leveraging the immune system to attack tumors. However, its effectiveness is often hindered by the immunosuppressive tumor microenvironment (TME), where a complex interplay of tumor, stromal, and immune cells undermines antitumor responses and allows tumors to evade immune detection. This review explores innovative strategies to modify the TME and enhance immunotherapy outcomes, focusing on the therapeutic potential of engineered bacteria. These bacteria exploit the unique characteristics of the TME, such as abnormal vasculature and immune suppression, to selectively accumulate in tumors. Genetically modified bacteria can deliver therapeutic agents, including immune checkpoint inhibitors and cytokines, directly to tumor sites. This review highlights how bacterial therapeutics can target critical immune cells within the TME, such as myeloid-derived suppressor cells and tumor-associated macrophages, thereby promoting antitumor immunity. The combination of bacterial therapies with immune checkpoint inhibitors or adoptive cell transfer presents a promising strategy to counteract immune suppression. Continued research in this area could position bacterial agents as a powerful new modality to reshape the TME and enhance the efficacy of cancer immunotherapy, particularly for tumors resistant to conventional treatments.
引用
收藏
页数:24
相关论文
共 50 条
  • [11] Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment
    Sun, Bo
    Hyun, Hyesun
    Li, Lian-tao
    Wang, Andrew Z.
    ACTA PHARMACOLOGICA SINICA, 2020, 41 (07) : 970 - 985
  • [12] The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy
    Ravindran, Shilpa
    Rasool, Saad
    Maccalli, Cristina
    CANCER MICROENVIRONMENT, 2019, 12 (2-3) : 133 - 148
  • [13] Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy
    Li, Qing
    Xiang, Ming
    ACTA PHARMACOLOGICA SINICA, 2022, 43 (06): : 1337 - 1348
  • [14] Optimizing Tumor Microenvironment for Cancer immunotherapy: β-Glucan-Based Nanoparticles
    Zhang, Mei
    Kim, Julian A.
    Huang, Alex Yee-Chen
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [15] Understanding the tumor microenvironment for effective immunotherapy
    Sadeghi Rad, Habib
    Monkman, James
    Warkiani, Majid E.
    Ladwa, Rahul
    O'Byrne, Ken
    Rezaei, Nima
    Kulasinghe, Arutha
    MEDICINAL RESEARCH REVIEWS, 2021, 41 (03) : 1474 - 1498
  • [16] Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer
    Economopoulou, Panagiota
    Kotsantis, Ioannis
    Psyrri, Amanda
    CANCERS, 2020, 12 (11) : 1 - 23
  • [17] The Role of Tumor Microenvironment in Cancer Immunotherapy
    Chen Xue-Man
    Song Er-Wei
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2017, 44 (08) : 641 - 648
  • [18] Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectiveness
    Barnestein, Robby
    Galland, Loick
    Kalfeist, Laura
    Ghiringhelli, Francois
    Ladoire, Sylvain
    Limagne, Emeric
    ONCOIMMUNOLOGY, 2022, 11 (01):
  • [19] Breaking Barriers: Modulation of Tumor Microenvironment to Enhance Bacillus Calmette-Guérin Immunotherapy of Bladder Cancer
    Ibrahim, Omar M.
    Kalinski, Pawel
    CELLS, 2024, 13 (08)
  • [20] The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy
    Salemme, Vincenzo
    Centonze, Giorgia
    Cavallo, Federica
    Defilippi, Paola
    Conti, Laura
    FRONTIERS IN ONCOLOGY, 2021, 11