Harnessing Bacterial Agents to Modulate the Tumor Microenvironment and Enhance Cancer Immunotherapy

被引:3
|
作者
Thomas, Christina James [1 ]
Delgado, Kaylee [1 ]
Sawant, Kamlesh [1 ]
Roy, Jacob [1 ]
Gupta, Udit [1 ]
Song, Carly Shaw [1 ]
Poojary, Rayansh [1 ]
de Figueiredo, Paul [2 ]
Song, Jianxun [1 ]
机构
[1] Texas A&M Univ, Hlth Sci Ctr, Dept Microbial Pathogenesis & Immunol, MREB 2,Room 3344,8447 John Sharp Pkwy, Bryan, TX 77807 USA
[2] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA
关键词
cancer immunotherapy; tumor microenvironment; engineered bacteria; immunosuppression; immune checkpoint inhibitors; bacterial therapeutics; antitumor immunity; ATTENUATED SALMONELLA-TYPHIMURIUM; METASTATIC BREAST-CANCER; ACTIVATION GENE-3 LAG-3; T-CELL DIFFERENTIATION; CLOSTRIDIUM-NOVYI-NT; SUPPRESSOR-CELLS; BACTERIOLYTIC THERAPY; DENDRITIC CELLS; IN-VITRO; HPV E7;
D O I
10.3390/cancers16223810
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer immunotherapy has revolutionized cancer treatment by leveraging the immune system to attack tumors. However, its effectiveness is often hindered by the immunosuppressive tumor microenvironment (TME), where a complex interplay of tumor, stromal, and immune cells undermines antitumor responses and allows tumors to evade immune detection. This review explores innovative strategies to modify the TME and enhance immunotherapy outcomes, focusing on the therapeutic potential of engineered bacteria. These bacteria exploit the unique characteristics of the TME, such as abnormal vasculature and immune suppression, to selectively accumulate in tumors. Genetically modified bacteria can deliver therapeutic agents, including immune checkpoint inhibitors and cytokines, directly to tumor sites. This review highlights how bacterial therapeutics can target critical immune cells within the TME, such as myeloid-derived suppressor cells and tumor-associated macrophages, thereby promoting antitumor immunity. The combination of bacterial therapies with immune checkpoint inhibitors or adoptive cell transfer presents a promising strategy to counteract immune suppression. Continued research in this area could position bacterial agents as a powerful new modality to reshape the TME and enhance the efficacy of cancer immunotherapy, particularly for tumors resistant to conventional treatments.
引用
收藏
页数:24
相关论文
共 50 条
  • [1] Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy
    Huang, Yu
    Fan, Hui
    Ti, Huihui
    ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2024, 19 (02)
  • [2] Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy
    Devaud, Christel
    John, Liza B.
    Westwood, Jennifer A.
    Darcy, Phillip K.
    Kershaw, Michael H.
    ONCOIMMUNOLOGY, 2013, 2 (08):
  • [3] The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment
    Yang, Muyue
    Li, Jipeng
    Gu, Ping
    Fan, Xianqun
    BIOACTIVE MATERIALS, 2021, 6 (07) : 1973 - 1987
  • [4] The Role of Tumor Microenvironment in Cancer Immunotherapy
    Frankel, Timothy
    Lanfranca, Mirna Perusina
    Zou, Weiping
    TUMOR IMMUNE MICROENVIRONMENT IN CANCER PROGRESSION AND CANCER THERAPY, 2017, 1036 : 51 - 64
  • [5] Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy
    Phuengkham, Hathaichanok
    Ren, Long
    Shin, Il Woo
    Lim, Yong Taik
    ADVANCED MATERIALS, 2019, 31 (34)
  • [7] Tumor-derived exosomes in the cancer immune microenvironment and cancer immunotherapy
    Tang, Qiushi
    Yang, Shuo
    He, Guangpeng
    Zheng, Hongyu
    Zhang, Sheng
    Liu, Jiaxing
    Wei, Shibo
    Fan, Qing
    Peng, Xueqiang
    Li, Xinyu
    Zhang, Dewei
    Yang, Liang
    Li, Hangyu
    CANCER LETTERS, 2022, 548
  • [8] Regulation of cancer-immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy
    Yang, Jingxing
    Zhang, Chunfu
    WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2020, 12 (04)
  • [9] Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy
    Musetti, Sara
    Huang, Leaf
    ACS NANO, 2018, 12 (12) : 11740 - 11755
  • [10] Targeting tumor immunosuppressive microenvironment for pancreatic cancer immunotherapy: Current research and future perspective
    Li, Ying
    Xiang, Shuai
    Pan, Wenjun
    Wang, Jing
    Zhan, Hanxiang
    Liu, Shanglong
    FRONTIERS IN ONCOLOGY, 2023, 13