Transcription factor EB, a promising therapeutic target in cardiovascular disease

被引：0

作者：

Yan, Xin ^{[1
]}

Yang, Li ^{[1
]}

Fu, Xiaolei ^{[1
]}

Luo, Xin ^{[1
]}

Wang, Chengming ^{[1
]}

Xie, Qiu Ping ^{[1
]}

Ouyang, Fan ^{[1
]}

机构：

[1] Cent South Univ, Zhuzhou Hosp, Dept Cardiovasc Med, Xiangya Sch Med, Zhuzhou, Peoples R China

来源：

PEERJ | 2024年 / 12卷

关键词：

Cardiovascular disease; TFEB; Lysosome; Autophagic flux; ACTIVATION; AUTOPHAGY; BIOGENESIS; APOPTOSIS;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cardiovascular disease (CVD) remains the major cause of morbidity and mortality around the world. Transcription factor EB (TFEB) is a master regulator of lysosome biogenesis and autophagy. Emerging studies revealed that TFEB also mediates cellular adaptation responses to various stimuli, such as mitochondrial dysfunction, pathogen infection and metabolic toxin. Based on its significant capability to modulate the autophagy-lysosome process (ALP), TFEB plays a critical role in the development of CVD. In this review, we briefly summarize that TFEB regulates cardiac dysfunction mainly through ameliorating lysosomal and mitochondrial dysfunction and reducing inflammation.

引用

页数：12

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