Advances in repetitive transcranial magnetic stimulation in the treatment of treatment-resistant depression: a comprehensive review

被引：1

作者：

Xing, Haoran ^{[3
]}

Liu, Xiaolei ^{[4
]}

Zhang, Yingying ^{[3
]}

Wu, Jie ^{[3
]}

Li, Mier ^{[3
]}

Ye, Hong ^{[5
]}

Ding, Yu ^{[6
]}

Wang, Weiwei ^{[1
]}

Zheng, Zhong ^{[2
]}

Bao, Tianhao ^{[3
]}

机构：

[1] Kunming Med Univ, Afliated Hosp 2, Dept Geriatr, 374 Dianmian Ave, Kunming 650101, Peoples R China

[2] Sichuan Univ, West China Xiamen Hosp, Ctr Neurol Funct Detect & Regulat, 699 Jinyuan West Rd,Xingbin St, Xiamen 361000, Peoples R China

[3] Kunming Med Univ, Yunnan Prov Mental Hosp, Affiliated Mental Hlth Ctr, Dept Sci & Educ, 733 Chuanjin Rd, Kunming 650224, Peoples R China

[4] Kunming Med Univ, Dept Neurol, Affiliated Hosp 1, Kunming 650032, Peoples R China

[5] Kunming Med Univ, Dept Pathol, Kunming 650500, Peoples R China

[6] Kunming Med Univ, Affiliated Hosp 2, Dept Ultrasound Med, Kunming 650101, Peoples R China

来源：

REVIEWS IN THE NEUROSCIENCES | 2025年 / 36卷 / 05期

基金：

中国国家自然科学基金;

关键词：

definition; mechanisms; repetitive transcranial magnetic stimulation; target areas; treatment-resistant depression; VENTROMEDIAL PREFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; RANDOMIZED DOUBLE-BLIND; CEREBRAL-BLOOD-FLOW; MAJOR DEPRESSION; INTERPERSONAL PSYCHOTHERAPY; ORBITOFRONTAL CORTEX; COMPARATIVE EFFICACY; FUNCTIONAL CONNECTIVITY; INFLAMMATORY MARKERS;

D O I：

10.1515/revneuro-2024-0151

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Major depressive disorder is a common mental disorder, and a significant number of patients exhibit poor response to conventional antidepressant treatments, known as treatment-resistant depression (TRD). However, the definition of TRD globally remains unclear, impeding clinical research, treatment development, outcome implementation, and policy-making. A wealth of research confirms that rTMS demonstrates promising efficacy in TRD. This paper elucidates the definition of TRD, summarizes potential targets of rTMS for treating TRD, comprehensively elaborates on the unique mechanisms, efficacy, and side effects of rTMS in treating TRD, and outlines considerations for special populations receiving rTMS treatment for TRD as well as other treatment modalities for TRD. Through these studies, we aim to provide more scientifically grounded recommendations for patients undergoing rTMS treatment for TRD.

引用

页码：545 / 576

页数：32

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