An insight into pharmacokinetics and dose optimization of antimicrobials agents in elderly patients

被引：1
作者：
Fu, Guanshuang [1 ,2 ]
Sun, Weijia [3 ]
Tan, Zhaoyi [1 ]
Liang, Beibei [1 ]
Cai, Yun [1 ]
机构：
[1] Peoples Liberat Army Gen Hosp, Ctr Med Clin Res, Dept Pharm, Beijing, Peoples R China
[2] Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China
[3] Peoples Liberat Army Gen Hosp, Med Supplies Ctr, Beijing, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷
关键词：
elderly; pharmacokinetics; antimicrobial agents; drug resistance; anti-infective therapy; POPULATION PHARMACOKINETICS; HEALTHY-YOUNG; ORAL BIOAVAILABILITY; DRUG-METABOLISM; SINGLE; PHARMACODYNAMICS; TOLERABILITY; TEICOPLANIN; THERAPY; KIDNEY;
D O I：
10.3389/fphar.2024.1396994
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The global elderly population is on the rise, and infections tend to have a higher mortality rate among older individuals. Aging is associated with the progressive impairment of multi-organ function, which can impact the pharmacokinetics of antimicrobials, potentially leading to the failure of anti-infective therapy. With the increasing life expectancy, a significant growth in the elderly demographic, and the escalating costs of healthcare, gaining a thorough understanding of pharmacokinetic changes in the elderly holds crucial clinical significance. This review compiles findings from published studies, offering a comprehensive overview of the pharmacokinetics of various antimicrobials in both adults and the elderly. Furthermore, it delves into advancements in pharmacokinetic methods specific to the elderly population.
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页数：15
相关论文
共 135 条
[21]   Prediction of plasma trough concentration of voriconazole in adult patients using machine learning [J].
Cheng, Lin ;
Zhao, Yue ;
Liang, Zaiming ;
You, Xi ;
Jia, Changsheng ;
Liu, Xiuying ;
Wang, Qian ;
Sun, Fengjun .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 188
[22]   Therapeutic drug monitoring and safety of voriconazole in elderly patients [J].
Cheng, Lin ;
Xiang, Rongfeng ;
Liu, Fang ;
Li, Yuliang ;
Chen, Heli ;
Yao, Pu ;
Sun, Fengjun ;
Xia, Peiyuan .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 78
[23]  
Chien RN, 1997, HEPATOLOGY, V25, P103, DOI 10.1002/hep.510250119
[24]   CLARITHROMYCIN PHARMACOKINETICS IN HEALTHY-YOUNG AND ELDERLY VOLUNTEERS [J].
CHU, SY ;
WILSON, DS ;
GUAY, DRP ;
CRAFT, C .
JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 32 (11) :1045-1049
[25]   AN OPEN STUDY TO COMPARE THE PHARMACOKINETICS, SAFETY AND TOLERABILITY OF A MULTIPLE-DOSE REGIMEN OF AZITHROMYCIN IN YOUNG AND ELDERLY VOLUNTEERS [J].
COATES, P ;
DANIEL, R ;
HOUSTON, AC ;
ANTROBUS, JHL ;
TAYLOR, T .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1991, 10 (10) :850-852
[26]  
Cojutti PG, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/AAC.02134-16, 10.1128/aac.02134-16]
[27]   Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects [J].
Cui, Cheng ;
Sia, Jie En Valerie ;
Tu, Siqi ;
Li, Xiaobei ;
Dong, Zhongqi ;
Yu, Zhiheng ;
Yao, Xueting ;
Hatley, Oliver ;
Li, Haiyan ;
Liu, Dongyang .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021, 87 (07) :2711-2722
[28]  
Danishuddin, 2022, DRUG DISCOV TODAY, V27, P529, DOI [DOI 10.1016/j.drudis.2021.09.013, 10.1016/j.drudis.2021.09.013]
[29]   Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania [J].
Denti, Paolo ;
Jeremiah, Kidola ;
Chigutsa, Emmanuel ;
Faurholt-Jepsen, Daniel ;
PrayGod, George ;
Range, Nyagosya ;
Castel, Sandra ;
Wiesner, Lubbe ;
Hagen, Christian Munch ;
Christiansen, Michael ;
Changalucha, John ;
McIlleron, Helen ;
Friis, Henrik ;
Andersen, Aase Bengaard .
PLOS ONE, 2015, 10 (10)
[30]   No Dose Adjustment for Isavuconazole Based on Age or Sex [J].
Desai, Amit V. ;
Han, David ;
Kowalski, Donna L. ;
Lademacher, Christopher ;
Pearlman, Helene ;
Yamazaki, Takao .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (06)
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