An insight into pharmacokinetics and dose optimization of antimicrobials agents in elderly patients

被引：1

作者：

Fu, Guanshuang ^{[1
,2
]}

Sun, Weijia ^{[3
]}

Tan, Zhaoyi ^{[1
]}

Liang, Beibei ^{[1
]}

Cai, Yun ^{[1
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Ctr Med Clin Res, Dept Pharm, Beijing, Peoples R China

[2] Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China

[3] Peoples Liberat Army Gen Hosp, Med Supplies Ctr, Beijing, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

关键词：

elderly; pharmacokinetics; antimicrobial agents; drug resistance; anti-infective therapy; POPULATION PHARMACOKINETICS; HEALTHY-YOUNG; ORAL BIOAVAILABILITY; DRUG-METABOLISM; SINGLE; PHARMACODYNAMICS; TOLERABILITY; TEICOPLANIN; THERAPY; KIDNEY;

D O I：

10.3389/fphar.2024.1396994

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The global elderly population is on the rise, and infections tend to have a higher mortality rate among older individuals. Aging is associated with the progressive impairment of multi-organ function, which can impact the pharmacokinetics of antimicrobials, potentially leading to the failure of anti-infective therapy. With the increasing life expectancy, a significant growth in the elderly demographic, and the escalating costs of healthcare, gaining a thorough understanding of pharmacokinetic changes in the elderly holds crucial clinical significance. This review compiles findings from published studies, offering a comprehensive overview of the pharmacokinetics of various antimicrobials in both adults and the elderly. Furthermore, it delves into advancements in pharmacokinetic methods specific to the elderly population.

引用

页数：15

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