Diterpenoid alkaloids from the roots of Aconitum bulbilliferum

被引：1

作者：

Luo, Yan-Yan ^{[1
,2
]}

Xu, Jin-Bu ^{[1
]}

Huang, Shuai ^{[1
]}

Zhou, Xian-Li ^{[1
,2
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China

[2] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Sichuan, Peoples R China

来源：

FITOTERAPIA | 2025年 / 181卷

基金：

中国国家自然科学基金;

关键词：

Aconitum bulbilliferum; Diterpenoid alkaloid; Bulbilliferine a; Denudatine-type; Analgesic activity; C-19-DITERPENOID ALKALOIDS; C19-DITERPENOID ALKALOIDS; NORDITERPENOID ALKALOIDS;

D O I：

10.1016/j.fitote.2025.106387

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The phytochemistry study of Aconitum bulbilliferum Hand.-Mazz. is firstly reported. Two C20-diterpenoid alkaloids, named bulbilliferines A and B (1 and 2 ), three C19-diterpenoid alkaloids, bulbillifedines A-C (3-5), and twenty known compounds (6-25) were isolated from the roots of A. bulbilliferum. The structures of these compounds were determined by the comprehensive spectroscopic analyses (HRESIMS, IR, 1D and 2D NMR). Among them, bulbilliferine A (1) is a denudatine-type diterpenoid alkaloid bearing a 16, 17-epoxy group. At a nontoxic dose of 10 mg/kg, 14-O-anisoylchasmanine (14) hydrochloride and austroconitine B (17) hydrochloride respectively exhibited the excellent analgesic effects with 83.6 % and 83.1 % inhibitions against acetic acid- induced writhing of mice.

引用

页数：7

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