Diterpenoid alkaloids from the roots of Aconitum bulbilliferum

被引:0
|
作者
Luo, Yan-Yan [1 ,2 ]
Xu, Jin-Bu [1 ]
Huang, Shuai [1 ]
Zhou, Xian-Li [1 ,2 ]
机构
[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
[2] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
Aconitum bulbilliferum; Diterpenoid alkaloid; Bulbilliferine a; Denudatine-type; Analgesic activity; C-19-DITERPENOID ALKALOIDS; C19-DITERPENOID ALKALOIDS; NORDITERPENOID ALKALOIDS;
D O I
10.1016/j.fitote.2025.106387
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The phytochemistry study of Aconitum bulbilliferum Hand.-Mazz. is firstly reported. Two C20-diterpenoid alkaloids, named bulbilliferines A and B (1 and 2 ), three C19-diterpenoid alkaloids, bulbillifedines A-C (3-5), and twenty known compounds (6-25) were isolated from the roots of A. bulbilliferum. The structures of these compounds were determined by the comprehensive spectroscopic analyses (HRESIMS, IR, 1D and 2D NMR). Among them, bulbilliferine A (1) is a denudatine-type diterpenoid alkaloid bearing a 16, 17-epoxy group. At a nontoxic dose of 10 mg/kg, 14-O-anisoylchasmanine (14) hydrochloride and austroconitine B (17) hydrochloride respectively exhibited the excellent analgesic effects with 83.6 % and 83.1 % inhibitions against acetic acid- induced writhing of mice.
引用
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页数:7
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