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Diterpenoid alkaloids from the roots of Aconitum bulbilliferum
被引:0
|作者:
Luo, Yan-Yan
[1
,2
]
Xu, Jin-Bu
[1
]
Huang, Shuai
[1
]
Zhou, Xian-Li
[1
,2
]
机构:
[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
[2] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Sichuan, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
Aconitum bulbilliferum;
Diterpenoid alkaloid;
Bulbilliferine a;
Denudatine-type;
Analgesic activity;
C-19-DITERPENOID ALKALOIDS;
C19-DITERPENOID ALKALOIDS;
NORDITERPENOID ALKALOIDS;
D O I:
10.1016/j.fitote.2025.106387
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
The phytochemistry study of Aconitum bulbilliferum Hand.-Mazz. is firstly reported. Two C20-diterpenoid alkaloids, named bulbilliferines A and B (1 and 2 ), three C19-diterpenoid alkaloids, bulbillifedines A-C (3-5), and twenty known compounds (6-25) were isolated from the roots of A. bulbilliferum. The structures of these compounds were determined by the comprehensive spectroscopic analyses (HRESIMS, IR, 1D and 2D NMR). Among them, bulbilliferine A (1) is a denudatine-type diterpenoid alkaloid bearing a 16, 17-epoxy group. At a nontoxic dose of 10 mg/kg, 14-O-anisoylchasmanine (14) hydrochloride and austroconitine B (17) hydrochloride respectively exhibited the excellent analgesic effects with 83.6 % and 83.1 % inhibitions against acetic acid- induced writhing of mice.
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页数:7
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