Evaluation of Image-Defined Risk Factor (IDRF) Assessment in Patients With Intermediate-risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531

被引：0

作者：

Brown, Erin G. ^{[1
]}

Adkins, E. Stanton ^{[2
]}

Mattei, Peter ^{[3
]}

Hoffer, Fredric A. ^{[4
]}

Wootton-Gorges, Sandra L. ^{[5
]}

London, Wendy B. ^{[6
,7
]}

Naranjo, Arlene ^{[8
]}

Schmidt, Mary L. ^{[9
]}

Hogarty, Michael D. ^{[10
]}

Irwin, Meredith S. ^{[11
]}

Cohn, Susan L. ^{[12
]}

Park, Julie R. ^{[13
]}

Maris, John M. ^{[14
]}

Bagatell, Rochelle

Twist, Clare J. ^{[15
]}

Nuchtern, Jed G. ^{[16
]}

Davidoff, Andrew M. ^{[17
]}

Newman, Erika A. ^{[18
]}

Lal, Dave R. ^{[19
]}

机构：

[1] Univ Calif Davis, Childrens Hosp, Dept Surg, Childrens Hosp, Sacramento, CA USA

[2] Univ South Carolina, Dept Pediat, Columbia, SC USA

[3] Childrens Hosp Philadelphia, Dept Surg, Div Cardiothorac Surg, Philadelphia, PA USA

[4] Univ Washington, Dept Radiol, Seattle, WA USA

[5] Univ Calif Davis, Dept Radiol, Childrens Hosp, Sacramento, CA USA

[6] Dana Farber Canc Inst, Dept Pediat, Boston, MA USA

[7] Boston Childrens Hosp, Boston, MA USA

[8] Univ Florida, Childrens Oncol Grp Stat & Data Ctr, Gainesville, FL USA

[9] Univ Illinois Canc Ctr, Dept Pediat, Div Pediat Hematol & Oncol, Chicago, IL USA

[10] Childrens Hosp Philadelphia, Dept Pediat, Div Pediat Hematol Oncol, Philadelphia, PA 19104 USA

[11] Hosp Sick Children, Dept Pediat, Div Pediat Hematol & Oncol, Toronto, ON, Canada

[12] UNIV CHICAGO, DEPT PEDIAT,DIV PEDIAT HEMATOL ONCOL, CHICAGO, IL 60637 USA

[13] St Jude Childrens Res Hosp, Ctr Appl Bioinformat, Memphis, TN USA

[14] Childrens Hosp Philadelphia, Dept Pediat, Div Oncol, Philadelphia, PA 19104 USA

[15] Roswell Pk Comprehens Canc Ctr, Dept Pediat, Buffalo, NY 14203 USA

[16] Texas Childrens Hosp, Dept Surg, Div Pediat Surg, Houston, TX USA

[17] St Jude Childrens Res Hosp, Dept Surg, Memphis, TN USA

[18] CS Mott Childrens Hosp, Dept Surg, Div Pediat Surg, Ann Arbor, MI USA

[19] Childrens Wisconsin, Dept Surg, Div Pediat Surg, Milwaukee, WI USA

来源：

JOURNAL OF PEDIATRIC SURGERY | 2025年 / 60卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Neuroblastoma; Image-defined risk factor; IDRF; Concordance;

D O I：

10.1016/j.jpedsurg.2024.161896

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: The International Neuroblastoma Risk Group (INRG) classifier utilizes a staging system based on pretreatment imaging criteria in which image-defined risk factors (IDRFs) are used to evaluate the extent of locoregional disease. Children's Oncology Group (COG) study ANBL0531 prospectively examined institutional determination of IDRF status and compared that to a standardized central review. Methods: Between 9/2009-6/2011, patients with intermediate-risk neuroblastoma were enrolled on ANBL0531 and had IDRF assessment at treating institutions. Paired COG pediatric surgeons and radiologists performed blinded central review of diagnostic imaging for the presence or absence of IDRFs. Second blinded review was performed in cases of discordance. Comparison of local and central review was performed using the Kappa coefficient to determine concordance in IDRF assessment. Results: 211 patients enrolled in ANBL0531 underwent IDRF assessment; 3 patients were excluded due to poor image quality. Central reviewer pairs agreed on the presence or absence of any IDRF in 170/208 (81.7%; K = 0.48) cases. Thirteen (6.3%) cases could not be adjudicated after second blinded review. Radiologists were more likely to identify IRDFs as present than surgeons (p < 0.001). Local and central reviewers agreed on the presence or absence of any IDRF in only108/208 (51.9%; K = 0.06) cases. Conclusions: Among experienced pediatric surgeons and radiologists participating in central review, concordance was moderate, with agreement in 81.7% of cases. On comparison of local and central assessment of IDRFs, concordance was poor. These data indicate that greater standardization, education, technology, and training are needed to improve the assessment of IDRFs in children with neuroblastoma. Level of Evidence: Treatment Study, Level III. (c) 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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