Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery

被引：2

作者：

Karabay, Arzu Zeynep ^{[1
]}

Barar, Jaleh ^{[2
]}

Hekmatshoar, Yalda ^{[3
]}

Saadat, Yalda Rahbar ^{[4
]}

机构：

[1] Ankara Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkiye

[2] Nova Southeastern Univ, Coll Pharm, Dept Pharmaceut Sci, Ft Lauderdale, FL 33328 USA

[3] Altinbas Univ, Fac Med, Dept Med Biol, TR-34217 Istanbul, Turkiye

[4] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz 5165665811, Iran

来源：

BIOMOLECULES | 2025年 / 15卷 / 03期

关键词：

plant-derived extracellular vesicle; exosome; immunomodulation; anticancer; anti-aging; anti-melanogenesis; detoxification; drug delivery; therapy; EXTRACELLULAR VESICLES; NANOVESICLES; NANOPARTICLES; CANCER; COLITIS; DOXORUBICIN; ARABIDOPSIS; METABOLISM; SECRETION; PATHWAY;

D O I：

10.3390/biom15030394

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most eukaryotic and prokaryotic cells have the potential to secrete a group of structures/membrane-bound organelles, collectively referred to as extracellular vesicles (EVs), which offer several advantages to producer/receiver cells. This review provides an overview of EVs from plant sources with emphasis on their health-promoting potential and possible use as therapeutic agents. This review highlights the essential biological effects of plant-derived extracellular vesicles, including immune modulation, anticancer activities, protection against chemical toxicity and pathogens, as well as anti-aging, anti-melanogenesis, and anti-arthritic effects, along with ongoing clinical studies. Evidence revealed that plant-derived EVs' contents exert their beneficial properties through regulating important signaling pathways by transferring miRNAs and other components. Taken all together, the data proposed that plant-derived EVs can be utilized as nutritional compounds and therapeutic agents, such as drug carriers. However, this emerging research area requires further in vitro/in vivo studies and clinical trials to determine the exact underlying mechanisms of EVs' positive health effects in treating various diseases.

引用

页数：30

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