Seasonal effect of PM2.5 exposure in patients with COPD: a multicentre panel study

被引:0
作者
Huh, Jin-Young [1 ,2 ]
Kim, Hajeong [1 ,3 ]
Park, Shinhee [4 ,5 ]
Ra, Seung Won [6 ]
Kang, Sung-Yoon [7 ]
Jung, Bock Hyun [4 ]
Kim, Mihye [4 ]
Lee, Sang Min [10 ]
Lee, Sang Pyo [7 ]
Lamichhane, Dirga Kumar [8 ]
Park, Young-Jun [9 ]
Lee, Seon-Jin [9 ]
Lee, Jae Seung [1 ]
Oh, Yeon-Mok [1 ]
Kim, Hwan-Cheol [8 ]
Lee, Sei Won [1 ]
机构
[1] Univ Ulsan, Asan Med Ctr, Dept Pulm & Crit Care Med, Coll Med,Clin Res Ctr Chron Obstruct Airway Dis, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea
[2] Chung Ang Univ, Gwangmyeong Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Gwangmyeong, South Korea
[3] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea
[4] Gangneung Asan Hosp, Dept Pulm Allergy & Crit Care Med, Kangnung, South Korea
[5] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Div Allergy & Resp Med, Bucheon, South Korea
[6] Univ Ulsan, Ulsan Univ Hosp, Dept Internal Med, Div Pulmonol,Coll Med, Ulsan, South Korea
[7] Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Pulmonol & Allergy, Incheon, South Korea
[8] Inha Univ, Dept Occupat & Environm Med, Coll Med, Incheon, South Korea
[9] Korea Res Inst Biosci & Biotechnol, Environm Dis Res Ctr, Daejeon, South Korea
[10] Dankook Univ, Coll Med, Dept Internal Med, Div Resp Dis & Allergy, Cheonan, South Korea
基金
新加坡国家研究基金会;
关键词
OBSTRUCTIVE PULMONARY-DISEASE; HOSPITAL ADMISSIONS; PARTICULATE MATTER; ULTRAFINE PARTICLES; DAILY MORTALITY; AIR-POLLUTION; NEVER-SMOKERS; TIME-SERIES; FINE; ASSOCIATION;
D O I
10.1039/d4em00376d
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Background: Exposure to particulate matter <2.5 mu m (PM2.5) is linked to chronic obstructive pulmonary disease (COPD), but most studies lack individual PM2.5 measurements. Seasonal variation and their impact on clinical outcomes remain understudied. Objective: This study investigated the impact of PM2.5 concentrations on COPD-related clinical outcomes and their seasonal changes. Methods: A multicentre panel study enrolled 105 COPD patients (age range: 46-82) from July 2019 to August 2020. Their mean forced expiratory volume in 1 second after bronchodilation was 53.9%. Individual PM2.5 levels were monitored continuously with indoor measurements at residences and outdoor data from the National Ambient Air Quality Monitoring Information System. Clinical parameters, including pulmonary function tests, symptom questionnaires (CAT and SGRQ-C), and impulse oscillometry (IOS), were assessed every three months over the course of one year. Statistical analysis was conducted using a linear mixed-effect model to account for repeated measurements and control for confounding variables, including age, sex, smoking status and socioeconomic status. Results: The mean indoor and outdoor PM2.5 concentrations were 16.2 +/- 8.4 mu g m(-3) and 17.2 +/- 5.0 mu g m(-3), respectively. Winter had the highest PM2.5 concentrations (indoor, 18.8 +/- 11.7 mu g m(3); outdoor, 22.5 +/- 5.0 mu g m(-3)). Higher PM2.5 concentrations significantly correlated with poorer St. George's Respiratory Questionnaire for COPD (SGRQ-C) scores and increased acute exacerbations, particularly in winter. Patients of lower socioeconomic status were more vulnerable. Increased PM2.5 concentrations were also associated with amplified small airway resistance (R5-R20). Conclusions: PM2.5 concentration changes are positively correlated with poorer SGRQ-C scores and increased acute exacerbations in COPD patients with significant seasonal variations, especially in winter.
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页数:9
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