Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline

被引：1

作者：

Saukkonen, Jussi J. ^{[8
,10
]}

Duarte, Raquel ^{[1
,2
,3
]}

Munsiff, Sonal S. ^{[4
]}

Winston, Carla A. ^{[11
]}

Mammen, Manoj J. ^{[5
]}

Abubakar, Ibrahim ^{[12
]}

Acuna-Villaorduna, Carlos ^{[9
,14
]}

Barry, Pennan M. ^{[15
]}

Bastos, Mayara L. ^{[16
,17
]}

Carr, Wendy ^{[11
]}

Chami, Hassan ^{[18
]}

Chen, Lisa L. ^{[7
]}

Chorba, Terence ^{[11
]}

Daley, Charles L. ^{[19
,20
]}

Garcia-Prats, Anthony J. ^{[21
,22
]}

Holland, Kelly ^{[23
]}

Konstantinidis, Ioannis ^{[24
,25
]}

Lipman, Marc ^{[13
,26
]}

Migliori, Giovanni Battista ^{[27
]}

Parvez, Farah M. ^{[11
]}

Shapiro, Adrienne E. ^{[28
,29
]}

Sotgiu, Giovanni ^{[30
]}

Starke, Jeffrey R. ^{[31
]}

Starks, Angela M. ^{[11
]}

Thakore, Sanket ^{[32
]}

Wang, Shu-Hua ^{[33
]}

Wortham, Jonathan M. ^{[11
]}

Nahid, Payam ^{[6
]}

Infect Dis Soc Amer

机构：

[1] Univ Porto, EPIUnit Inst Saude Publ, Porto, Portugal

[2] ARS Norte, Unidade Invest Clin, Porto, Portugal

[3] Ctr Hosp Vila Nova de Gaia Espinho, Serv Pneumol, Vila Nova De Gaia, Portugal

[4] Univ Rochester, Sch Med & Dent, Dept Med, Div Infect Dis, Rochester, NY USA

[5] Univ Rochester, Sch Med & Dent, Dept Med, Div Pulm & Crit Care, Rochester, NY USA

[6] Univ Calif San Francisco, Zuckerberg San Francisco Gen Hosp & Trauma Ctr, UCSF Off Res, San Francisco, CA USA

[7] Univ Calif San Francisco, Curry Int TB Ctr, UCSF Ctr TB, Zuckerberg San Francisco Gen Hosp & Trauma Ctr,UCS, San Francisco, CA USA

[8] Boston Univ, Div Pulm & Crit Care Med, Chobanian & Avedisian Sch Med, Charlottesville, VA USA

[9] Boston Univ, Chobanian & Avedisian Sch Med, Dept Med, Sect Infect Dis, Boston, MA USA

[10] Boston Vet Adm Hlth Care Syst, West Roxbury, MA USA

[11] US Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA

[12] UCL, Fac Populat Hlth Sci, London, England

[13] UCL, Fac Med, UCL Resp Med, London, England

[14] Lemuel Shattuck Hosp, Massachusetts Dept Publ Hlth, Boston, MA USA

[15] Calif Dept Publ Hlth, Ctr Infect Dis, Div Communicable Dis Control, TB Control Branch, Richmond, CA USA

[16] McGill Univ, Fac Med, McGill Int TB Ctr, Montreal, PQ, Canada

[17] Univ Manitoba, Max Rady Coll Med, Dept Family Med, Winnipeg, MB, Canada

[18] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD USA

[19] Natl Jewish Hlth, Dept Med, Div Mycobacterial & Resp Infect, Denver, CO USA

[20] Univ Colorado, Sch Med, Denver, CO USA

[21] Univ Wisconsin Madison, Sch Med & Publ Hlth, Dept Pediat, Madison, WI USA

[22] Stellenbosch Univ, Fac Med & Hlth Sci, Desmond Tutu TB Ctr, Dept Paediat & Child Hlth, Cape Town, South Africa

[23] We Are TB, Pittsburgh, PA USA

[24] Vet Affairs Pittsburgh Hlth Care Syst, Dept Med, Div Pulm Allergy Crit Care & Sleep Med, Pittsburgh, PA 15260 USA

[25] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA

[26] Royal Free Hosp, Resp Med, London, England

[27] Ist Ricovero & Cura Carattere Sci, Serv Epidemiol Clin Malattie Resp, Ist Clin Sci Maugeri, Tradate, Italy

[28] Univ Washington, Dept Med, Seattle, WA USA

[29] Univ Washington, Dept Med, Div Allergy & Infect Dis, Seattle, WA USA

[30] Univ Sassari, Dept Med Surg & Pharm, Clin Epidemiol & Med Stat Unit, Sassari, Italy

[31] Baylor Coll Med, Dept Pediat, Houston, TX USA

[32] Yale Univ, Dept Internal Med, Yale Sch Med, Sect Pulm Crit Care & Sleep Med, New Haven, CT USA

[33] Ohio State Univ, Coll Med, Dept Internal Med, Div Infect Dis, Columbus, OH USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2025年 / 211卷 / 01期

关键词：

tuberculosis; drug-resistant; drug-susceptible; children; adults; RIFAMPIN-RESISTANT; UNITED-STATES; RECOMMENDATIONS; BEDAQUILINE; REGIMEN; MOXIFLOXACIN; PRETOMANID; TB;

D O I：

10.1164/rccm.202410-2096ST

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: On the basis of recent clinical trial data for the treatment of drug-susceptible and drug-resistant tuberculosis (TB), the American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America have updated clinical practice guidelines for TB treatment in children and adults in settings in which mycobacterial cultures, molecular and phenotypic drug susceptibility tests, and radiographic studies, among other diagnostic tools, are available on a routine basis. Methods: A Joint Panel representing multiple interdisciplinary perspectives convened with American Thoracic Society methodologists to review evidence and make recommendations using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and GRADE-ADOLOPMENT (adoption, adaptation, and, as needed, de novo development of recommendations) methodology. Results: New drug-susceptible TB recommendations include the use of a novel 4-month regimen for people with pulmonary TB and a shortened 4-month regimen for children with nonsevere TB. Drug-resistant TB recommendation updates include the use of novel regimens containing bedaquiline, pretomanid, and linezolid with or without moxifloxacin. Conclusions: All-oral, shorter treatment regimens for TB are now recommended for use in eligible individuals

引用

页码：15 / 33

页数：19

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