Advancements in the Treatment of Atherosclerosis: From Conventional Therapies to Cutting-Edge Innovations

被引:1
作者
Liu, Yan [1 ,2 ]
Lu, Kuan [1 ]
Zhang, Ruru [2 ]
Hu, Dongliang [1 ,2 ]
Yang, Zhe [1 ]
Zeng, Jianfeng [2 ]
Cai, Wu [1 ]
机构
[1] Soochow Univ, Affiliated Hosp 2, Suzhou 215000, Peoples R China
[2] Soochow Univ, Ctr Mol Imaging & Nucl Med, Sch Radiol & Interdisciplinary Sci RAD X, State Key Lab Radiat Med & Protect,Collaborat Inno, Suzhou 215123, Peoples R China
基金
中国国家自然科学基金;
关键词
Atherosclerosis; Pharmacological therapies; Nanomedicine; Cardiovascular disease prevention; CORONARY-ARTERY-DISEASE; PLAQUE STABILIZATION; INTERVENTION; INFLAMMATION; MICE; RISK; REVASCULARIZATION; NANOPARTICLES; METABOLISM; COLCHICINE;
D O I
10.1021/acsptsci.4c00574
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Atherosclerosis is a leading cause of morbidity and mortality worldwide, driven by a complex interplay of lipid dysregulation, inflammation, and vascular pathology. Despite advancements in understanding the multifactorial nature of atherosclerosis and improvements in clinical management, existing therapies often fall short in reversing the disease, focusing instead on symptom alleviation and risk reduction. This review highlights recent strides in identifying genetic markers, elucidating inflammatory pathways, and understanding environmental contributors to atherosclerosis. It also evaluates the efficacy and limitations of current pharmacological treatments, revascularization techniques, and the impact of these interventions on patient outcomes. Furthermore, we explore innovative therapeutic strategies, including the promising fields of nanomedicine, nucleic acid-based therapies, and immunomodulation, which offer potential for targeted and effective treatment modalities. However, integrating these advances into clinical practice is challenged by regulatory, economic, and logistical barriers. This review synthesizes the latest research and clinical advancements to provide a comprehensive roadmap for future therapeutic strategies and emphasize the critical need for innovative approaches to fundamentally change the course of atherosclerosis management.
引用
收藏
页码:3804 / 3826
页数:23
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