Effects and mechanisms of Helicobacter pylori infection on the occurrence of extra-gastric tumors

被引：4
作者：
Zhao, Shi-Qing [1 ,2 ]
Zheng, Hui-Ling [3 ]
Zhong, Xiao-Tian [1 ,2 ]
Wang, Zi-Ye [1 ,2 ]
Su, Yi [1 ,2 ]
Shi, Yan-Yan [1 ]
机构：
[1] Peking Univ Third Hosp, Res Ctr Clin Epidemiol, 49 Garden North Rd, Beijing 100191, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Beijing 100191, Peoples R China
[3] Peking Univ Third Hosp, Dept Gastroenterol, Beijing 100191, Peoples R China
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2024年 / 30卷 / 37期
基金：
北京市自然科学基金;
关键词：
Helicobacter pylori; Extra-gastric tumors; Immune system response; Mucosal barrier; Gut microbiome; SQUAMOUS-CELL CARCINOMA; COLORECTAL ADENOMA; EPITHELIAL-CELLS; URINARY-BLADDER; CANCER; RISK; ADENOCARCINOMA; CYCLOOXYGENASE-2; INFLAMMATION; ASSOCIATION;
D O I：
10.3748/wjg.v30.i37.4090
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Helicobacter pylori (H. pylori) colonizes the human stomach and many studies have discussed the mechanisms of H. pylori infection leading to gastric diseases, including gastric cancer. Additionally, increasing data have shown that the infection of H. pylori may contribute to the development of extra-gastric diseases and tumors. Inflammation, systemic immune responses, microbiome disorders, and hypergastrinemia caused by H. pylori infection are associated with many extra-gastric malignancies. This review highlights recent discoveries; discusses the relationship between H. pylori and various extra-gastric tumors, such as colorectal cancer, lung cancer, cholangiocarcinoma, and gallbladder carcinoma; and explores the mechanisms of extra-gastric carcinogenesis by H. pylori. Overall, these findings refine our understanding of the pathogenic processes of H. pylori, provide guidance for the clinical treatment and management of H. pylori-related extra-gastric tumors, and help improve prognosis.
引用
收藏
页码：4090 / 4103
页数：15
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