Empirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines

被引:5
作者
Kaltsas, Aris [1 ]
Zachariou, Athanasios [2 ]
Dimitriadis, Fotios [3 ]
Chrisofos, Michael [1 ]
Sofikitis, Nikolaos [2 ]
机构
[1] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Dept Urol 3, Athens 12462, Greece
[2] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Urol, Ioannina 45110, Greece
[3] Aristotle Univ Thessaloniki, Fac Med, Sch Hlth Sci, Dept Urol, Thessaloniki 54124, Greece
关键词
male infertility; lifestyle modifications; medical treatments; sperm quality; reproductive health; IDIOPATHIC MALE-INFERTILITY; FOLLICLE-STIMULATING-HORMONE; IN-VITRO FERTILIZATION; DOUBLE-BLIND; ANTIOXIDANT THERAPY; CIGARETTE-SMOKING; OXIDATIVE STRESS; ALPHA-BLOCKER; SEMEN QUALITY; EXOGENOUS TESTOSTERONE;
D O I
10.3390/diseases12090209
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background/Objectives: Male infertility is a prevalent issue impacting numerous couples worldwide. This review aims to evaluate the effectiveness of empirical therapies for male infertility, focusing on both lifestyle modifications and medical treatments. This study provides a comprehensive overview of interventions aimed at improving male fertility outcomes. Methods: A thorough review of the existing literature was conducted, encompassing studies on lifestyle changes such as dietary changes, smoking cessation, alcohol moderation, and exercise. Additionally, medical treatments including selective estrogen receptor modulators, gonadotropins, aromatase inhibitors, phosphodiesterase-5 inhibitors, antioxidants, dopamine agonists, kallikrein, indomethacin, low-dose corticosteroids, alpha-blockers, and nitric oxide donors were evaluated. The study population included males diagnosed with infertility, focusing on various underlying causes. Results: Lifestyle modifications were found to have a positive impact on sperm quality. Evidence shows that a healthy diet, smoking cessation, moderate alcohol consumption, and regular exercise improve fertility outcomes. Medical treatments demonstrated significant improvements in sperm production and quality. Selective estrogen receptor modulators and gonadotropins enhanced sperm parameters. Aromatase inhibitors and phosphodiesterase-5 inhibitors specifically improved sperm motility and increased pregnancy rates. Antioxidants, such as vitamins E and C and coenzyme Q10, reduced oxidative stress and enhanced sperm counts, motility, and morphology. Dopamine agonists, particularly cabergoline, normalized prolactin levels and improved fertility outcomes. Kallikrein therapy improved sperm parameters and increased pregnancy rates. Indomethacin treatment was associated with increased sperm concentrations and motility. Low-dose corticosteroids and alpha-blockers showed variable results, and nitric oxide donors like L-arginine enhanced sperm counts and motility. Conclusions: Empirical therapies, including lifestyle modifications and medical treatments, significantly enhance sperm quality and reproductive potential. These integrated approaches are essential in improving fertility outcomes in males. However, further extensive randomized trials are necessary to definitively establish the most effective treatments.
引用
收藏
页数:21
相关论文
共 119 条
  • [1] Effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in men with idiopathic oligozoospermia
    Adamopoulos, DA
    Pappa, A
    Billa, E
    Nicopoulou, S
    Koukkou, E
    Michopoulos, J
    [J]. FERTILITY AND STERILITY, 2003, 80 (04) : 914 - 920
  • [2] Correlation of reactive oxygen species levels with the fertilization rate after in vitro fertilization: a qualified meta-analysis
    Agarwal, A
    Allamaneni, SSR
    Nallella, KP
    George, AT
    Mascha, E
    [J]. FERTILITY AND STERILITY, 2005, 84 (01) : 228 - 231
  • [3] Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
    Agarwal, Ashok
    Parekh, Neel
    Selvam, Manesh Kumar Panner
    Henkel, Ralf
    Shah, Rupin
    Homa, Sheryl T.
    Ramasamy, Ranjith
    Ko, Edmund
    Tremellen, Kelton
    Esteves, Sandro
    Majzoub, Ahmad
    Alvarez, Juan G.
    Gardner, David K.
    Jayasena, Channa N.
    Ramsay, Jonathan W.
    Cho, Chak-Lam
    Saleh, Ramadan
    Sakkas, Denny
    Hotaling, James M.
    Lundy, Scott D.
    Vij, Sarah
    Marmar, Joel
    Gosalvez, Jaime
    Sabanegh, Edmund
    Park, Hyun Jun
    Zini, Armand
    Kavoussi, Parviz
    Micic, Sava
    Smith, Ryan
    Busetto, Gian Maria
    Bakircioglu, Mustafa Emre
    Haidl, Gerhard
    Balercia, Giancarlo
    Garrido Puchalt, Nicols
    Ben-Khalifa, Moncef
    Tadros, Nicholas
    Kirkman-Browne, Jackson
    Moskovtsev, Sergey
    Huang, Xuefeng
    Borges, Edson, Jr.
    Franken, Daniel
    Bar-Chama, Natan
    Morimoto, Yoshiharu
    Tomita, Kazuhisa
    Srini, Vasan Satya
    Ombelet, Willem
    Baldi, Elisabetta
    Muratori, Monica
    Yumura, Yasushi
    La Vignera, Sandro
    [J]. WORLD JOURNAL OF MENS HEALTH, 2019, 37 (03) : 296 - 312
  • [4] Ahmadi-Asrbadr Y, 2022, AM J CLIN EXP UROL, V10, P258
  • [5] BROMOCRIPTINE THERAPY IN OLIGOZOOSPERMIC INFERTILE MEN
    AINMELK, Y
    BELISLE, S
    KANDALAFT, N
    MCCLURE, D
    TETREAULT, L
    ELHILALI, M
    [J]. ARCHIVES OF ANDROLOGY, 1982, 8 (02): : 135 - 141
  • [6] The physiology of male reproduction: Impact of drugs and their abuse on male fertility
    Ajayi, Ayodeji Folorunsho
    Akhigbe, Roland Eghoghosoa
    [J]. ANDROLOGIA, 2020, 52 (09)
  • [7] Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre- and post-coenzyme Q10 therapy
    Alahmar, Ahmed T.
    Naemi, Roozbeh
    [J]. ANDROLOGIA, 2022, 54 (05)
  • [8] Coenzyme Q10, oxidative stress markers, and sperm DNA damage in men with idiopathic oligoasthenoteratospermia
    Alahmar, Ahmed T.
    Sengupta, Pallav
    Dutta, Sulagna
    Calogero, Aldo E.
    [J]. CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM, 2021, 48 (02): : 150 - 155
  • [9] An Q, 2020, INT J CLIN EXP PATHO, V13, P1287
  • [10] Antioxidant Intervention against Male Infertility: Time to Design Novel Strategies
    avila, Cristobal
    Vinay, Jose Ignacio
    Arese, Marzia
    Saso, Luciano
    Rodrigo, Ramon
    [J]. BIOMEDICINES, 2022, 10 (12)