Prevalence and associated factors of metabolic syndrome among patients with severe mental illness attending Amanuel Mental Specialized Hospital in Addis Ababa, Ethiopia: hospital-based cross-sectional study

被引：0
作者：
Helena Getenet [1 ]
Yeweyenhareg Feleke [1 ]
Ruth Tsigebrhan [2 ]
Tadesse Lejisa [3 ]
Genet Ashebir [3 ]
机构：
[1] Department of Internal Medicine, Endocrinology and Metabolism Unit, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa
[2] Department of Psychiatryand, School of Medicine, WHO Collaborating Center in Mental Health Research and Capacity-Building, College of Health Sciences, Addis Ababa University, Addis Ababa
[3] National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa
来源：
BMC Psychiatry | / 25卷 / 1期
关键词：
Bipolar disorder; Major depressive disorder; Metabolic syndrome; Schizophrenia; Severe mental illness;
D O I：
10.1186/s12888-025-06845-w
中图分类号：
学科分类号：
摘要：
Background: Metabolic syndrome (MetS) is the leading cause of mortality and morbidity in patients with severe mental illness (SMI). The present study was designed to determine the prevalence and associated factors of MetS among people with SMI attending the Amanuel Mental Specialized Hospital in Addis Ababa, Ethiopia. Methods: A hospital-based cross-sectional study was conducted among people with SMI attending the outpatient psychiatric department. Socio-demographic and other clinical data were collected using a structured questionnaire. A standardized chemistry analyzer measured lipid profiles and blood glucose levels at the Ethiopian Public Health Institute. Univariable and multivariable logistic regression analysis was conducted to examine the association of the outcome with clinical and socio-demographic variables. Results: A total of 305 participants with SMI were recruited, 79% (n = 241) were male. The overall prevalence of MetS was 28.5% (n = 87), 31.5% (n = 63) among all the participants diagnosed with schizophrenia, and 25% (n = 13) among participants diagnosed with bipolar disorders. The most frequent metabolic abnormality was low high-density lipoprotein (HDL) 88.5% (n = 77). About 54% (n = 47) had abnormal waist circumference; 27.5% (n = 84) of the participants had a blood pressure of ≥ 130/85 mmHg; 4.6% (n = 14) had fasting blood glucose above 100 mg/dl; and 36.4% (n = 111) had triglyceride levels above 150 mg/dl. On multivariable analysis, increasing age (Adjusted odds ratio (aOR) = 1.12, 95% CI 1.08, 1.16) and having secondary education and above (aOR = 2.64, 95% CI 1.24, 5.50) compared to primary education, increasing duration of treatment (aOR = 1.11, 95% CI 1.03, 1.18) and alcohol use (aOR = 1.89, 95% CI 1.03, 3.47) were associated with MetS. 27.2% (n = 83) of the participants with SMI were overweight, and 4.6% (n = 14) had obesity. Increasing age (aOR = 1.11, 95% CI 1.05, 1.14), being female (aOR = 2.42, 95% CI 1.17, 5.01), smoking (aOR = 2.83, 95% CI 1.30, 6.15) and use of second-generation antipsychotics (aOR = 2.64, 95% CI 1.41, 4.94) were significantly associated with being overweight/obesity. Conclusions: Individuals with SMI receiving care at a tertiary healthcare facility in Ethiopia exhibited a high prevalence of overweight/obesity and MetS. Therefore, health education and early screening for the components of MetS in this vulnerable population are recommended. © The Author(s) 2025.
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  • [1] Li X., Zhai Y., Zhao J., He H., Li Y., Liu Y., Et al., Impact of metabolic syndrome and it's components on prognosis in patients with cardiovascular diseases: a meta-analysis, Frontiers in Cardiovascular Medicine, 8, (2021)
  • [2] NCEPEPo D., ToHBCi A., Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III): The Program, (2002)
  • [3] Lindsay R.S., Howard B.V., Cardiovascular risk associated with the metabolic syndrome, Curr DiabRep, 4, 1, pp. 63-68, (2004)
  • [4] Noubiap J.J., Nansseu J.R., Lontchi-Yimagou E., Nkeck J.R., Nyaga U.F., Ngouo A.T., Et al., Geographic distribution of metabolic syndrome and its components in the general adult population: A meta-analysis of global data from 28 million individuals, Diabetes Res Clin Pract, 188, (2022)
  • [5] Park Y.-W., Zhu S., Palaniappan L., Heshka S., Carnethon M.R., Heymsfield S.B., The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994, Arch Intern Med, 163, 4, pp. 427-436, (2003)
  • [6] Jemere T., Kefale B., Metabolic syndrome and its associated factors in Ethiopia: A systematic review and meta-analysis, J Diabetes Metab Disord, 20, pp. 1021-1031, (2021)
  • [7] Ambachew S., Endalamaw A., Worede A., Tegegne Y., Melku M., Biadgo B., The Prevalence of Metabolic Syndrome in Ethiopian Population: A Systematic Review and Meta-analysis, Journal of obesity, 2020, 1, (2020)
  • [8] Toalson P., Ahmed S., Hardy T., Kabinoff G., The metabolic syndrome in patients with severe mental illnesses, Primary care companion to the Journal of clinical psychiatry, 6, 4, (2004)
  • [9] Vancampfort D., Vansteelandt K., Correll C.U., Mitchell A.J., De Herdt A., Sienaert P., Et al., Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderators, Am J Psychiatry, 170, 3, pp. 265-274, (2013)
  • [10] Challa F., Getahun T., Sileshi M., Geto Z., Kelkile T.S., Gurmessa S., Et al., Prevalence of metabolic syndrome among patients with schizophrenia in Ethiopia, BMC Psychiatry, 21, pp. 1-9, (2021)
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