Twisted Cucurbit[14]uril-Based Supramolecular Self-Assembly Induces Fluorescence Emission of Dye Molecules for Multi-Channel Cell Imaging

被引：0

作者：

Yuan, Xing-Yue ^{[1
]}

Xiao, Han ^{[2
]}

Wu, Li ^{[1
]}

Zhao, Jie ^{[1
]}

Wu, Jia-Rui ^{[3
]}

Ni, Yu ^{[3
]}

Xiao, Xin ^{[1
]}

Yang, Hai-Ping ^{[2
]}

机构：

[1] Guizhou Univ, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang 550025, Peoples R China

[2] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Nephrol,Minist Educ,Key Lab Child Dev & Disor, Chongqing 400042, Peoples R China

[3] Guiyang No 3 Expt High Sch, Guiyang 550001, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2025年

基金：

中国国家自然科学基金;

关键词：

Twisted cucurbit[14]uril; Self-Assembly; Supermolecule; Fluorescent material; Cell imaging; RECOGNITION; CATIONS; GUEST;

D O I：

10.1002/chem.202404257

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, a supramolecular fluorescent material was constructed by using double-cavity twisted cucurbit[14]uril (tQ[14]) and positively charged Astrazon Pink FG (APFG) based on the non-covalent host-guest interaction for the first time. The thermodynamic parameters of the APFG@tQ[14] in aqueous solution were determined by isothermal titration calorimetry (ITC), the results indicated that the spontaneous assembly of APFG@tQ[14] is mainly driven by enthalpy. The intramolecular charge transfer (ICT) effect induced the APFG@tQ[14] probe to emit a strong orange-red fluorescence. Due to its good optical properties and low toxicity, APFG@tQ[14] was successfully applied to multi-channel imaging of HK2 cells. This demonstrates the great potential of APFG@tQ[14] in labeling and tracking living cells.

引用

页数：7