LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization

被引：0

作者：

Wang, Juan ^{[1
]}

Wang, Jing ^{[2
]}

Zhong, Jiuchang ^{[1
]}

Liu, Hongbin ^{[3
]}

Li, Weiming ^{[1
]}

Chen, Mulei ^{[1
]}

Xu, Li ^{[1
]}

Zhang, Wenbin ^{[2
,4
]}

Zhang, Ze ^{[2
,4
]}

Wei, Zhizhong ^{[2
]}

Guo, Jia ^{[2
,4
]}

Wang, Xinyu ^{[1
]}

Sui, Jianhua ^{[2
]}

Liu, Xingpeng ^{[1
]}

Zhang, Sitao ^{[2
,4
]}

Wang, Xiaodong ^{[1
,2
,4
]}

机构：

[1] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Key Lab Hypertens, Heart Ctr, Beijing 100020, Peoples R China

[2] Natl Inst Biol Sci, Beijing 102206, Peoples R China

[3] Beijing 301 Hosp, Med Ctr 2, Dept Cardiol, Beijing 100853, Peoples R China

[4] Tsinghua Univ, Tsinghua Inst Multidisciplinary Biomed Res, Beijing 102206, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2024年 / 121卷 / 35期

关键词：

atherosclerosis; macrophage; LRG1; inflammation; IMMUNOMETABOLISM; INFLAMMATION; DISEASE; BIOMARKERS; MONOCYTE; CELLS; JNK;

D O I：

10.1073/pnas.2405845121

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by the accumulation of cholesterol- rich lipoproteins in macrophages. How macrophages commit to proinflammatory polarization under atherosclerosis conditions is not clear. Report here that the level of a circulating protein, leucine- rich alpha- 2 glycoprotein 1 (LRG1), is elevated in the atherosclerotic tissue and serum samples from patients with coronary ization through the activation of extracellular signal- regulated kinase 1/2 (ERK1/2) and delayed atherogenesis progression and reduced levels of macrophage- related proinflamM1- like polarization in vitro and conferred therapeutic benefits to animals with ApoE deficiency- induced atherosclerosis. LRG1 may therefore serve as an additional biomarker patients by mitigating the proinflammatory response of macrophages.

引用

页数：11

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