LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization

被引：0
作者：
Wang, Juan [1 ]
Wang, Jing [2 ]
Zhong, Jiuchang [1 ]
Liu, Hongbin [3 ]
Li, Weiming [1 ]
Chen, Mulei [1 ]
Xu, Li [1 ]
Zhang, Wenbin [2 ,4 ]
Zhang, Ze [2 ,4 ]
Wei, Zhizhong [2 ]
Guo, Jia [2 ,4 ]
Wang, Xinyu [1 ]
Sui, Jianhua [2 ]
Liu, Xingpeng [1 ]
Zhang, Sitao [2 ,4 ]
Wang, Xiaodong [1 ,2 ,4 ]
机构：
[1] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Key Lab Hypertens, Heart Ctr, Beijing 100020, Peoples R China
[2] Natl Inst Biol Sci, Beijing 102206, Peoples R China
[3] Beijing 301 Hosp, Med Ctr 2, Dept Cardiol, Beijing 100853, Peoples R China
[4] Tsinghua Univ, Tsinghua Inst Multidisciplinary Biomed Res, Beijing 102206, Peoples R China
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2024年 / 121卷 / 35期
关键词：
atherosclerosis; macrophage; LRG1; inflammation; IMMUNOMETABOLISM; INFLAMMATION; DISEASE; BIOMARKERS; MONOCYTE; CELLS; JNK;
D O I：
10.1073/pnas.2405845121
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by the accumulation of cholesterol- rich lipoproteins in macrophages. How macrophages commit to proinflammatory polarization under atherosclerosis conditions is not clear. Report here that the level of a circulating protein, leucine- rich alpha- 2 glycoprotein 1 (LRG1), is elevated in the atherosclerotic tissue and serum samples from patients with coronary ization through the activation of extracellular signal- regulated kinase 1/2 (ERK1/2) and delayed atherogenesis progression and reduced levels of macrophage- related proinflamM1- like polarization in vitro and conferred therapeutic benefits to animals with ApoE deficiency- induced atherosclerosis. LRG1 may therefore serve as an additional biomarker patients by mitigating the proinflammatory response of macrophages.
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页数：11
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