Preventive Effects of Hochuekkito on Decline in Brain-Derived Neurotrophic Factor Serum Levels in Senescence-Accelerated Mouse Prone 10

被引：1
作者：
Nakajima, Kensuke [1 ]
Idegami, Aimi [1 ]
Oiso, Shigeru [1 ,2 ]
机构：
[1] Nagasaki Int Univ, Fac Pharmaceut Sci, Dept Pharm, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 8593298, Japan
[2] Nagasaki Int Univ, Grad Sch Pharmaceut Sci, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 8593298, Japan
来源：
JOURNAL OF OLEO SCIENCE | 2025年 / 74卷 / 04期
基金：
日本学术振兴会;
关键词：
senescence-accelerated mouse prone 10; brain-derived neurotrophic factor; Hochuekkito; serum; ALZHEIMERS-DISEASE; UP-REGULATION; BDNF SERUM; MODEL; IDENTIFICATION; EXPRESSION; DEMENTIA; RISK; SAM;
D O I：
10.5650/jos.ess24328
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The reduction of brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease and depression. Senescence-accelerated mouse prone 10 (SAMP10), a rapid aging animal model, exhibits age-related cognitive deficits and depression-like behavior; however, it is unclear the variation of serum BDNF levels. Here, we showed that serum BDNF levels in SAMP10 were lower than those in the normal aging characteristics mouse SAM-resistant 1 (SAMR1), and Hochuekkito suppressed the decline of serum BDNF levels in SAMP10. These results suggest that SAMP10 may be used as an animal model in decreasing serum BDNF levels and Hochuekkito could prevent the age-related BDNF decline.
引用
收藏
页码：429 / 434
页数：6
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