Preventive Effects of Hochuekkito on Decline in Brain-Derived Neurotrophic Factor Serum Levels in Senescence-Accelerated Mouse Prone 10

被引：0
|
作者：
Nakajima, Kensuke [1 ]
Idegami, Aimi [1 ]
Oiso, Shigeru [1 ,2 ]
机构：
[1] Nagasaki Int Univ, Fac Pharmaceut Sci, Dept Pharm, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 8593298, Japan
[2] Nagasaki Int Univ, Grad Sch Pharmaceut Sci, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 8593298, Japan
来源：
JOURNAL OF OLEO SCIENCE | 2025年 / 74卷 / 04期
基金：
日本学术振兴会;
关键词：
senescence-accelerated mouse prone 10; brain-derived neurotrophic factor; Hochuekkito; serum; ALZHEIMERS-DISEASE; UP-REGULATION; BDNF SERUM; MODEL; IDENTIFICATION; EXPRESSION; DEMENTIA; RISK; SAM;
D O I：
10.5650/jos.ess24328
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The reduction of brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease and depression. Senescence-accelerated mouse prone 10 (SAMP10), a rapid aging animal model, exhibits age-related cognitive deficits and depression-like behavior; however, it is unclear the variation of serum BDNF levels. Here, we showed that serum BDNF levels in SAMP10 were lower than those in the normal aging characteristics mouse SAM-resistant 1 (SAMR1), and Hochuekkito suppressed the decline of serum BDNF levels in SAMP10. These results suggest that SAMP10 may be used as an animal model in decreasing serum BDNF levels and Hochuekkito could prevent the age-related BDNF decline.
引用
收藏
页码：429 / 434
页数：6
相关论文
共 50 条
  • [1] Serum brain-derived neurotrophic factor levels in epilepsy
    Hong, Z.
    Li, W.
    Qu, B.
    Zou, X.
    Chen, J.
    Sander, J. W.
    Zhou, D.
    EUROPEAN JOURNAL OF NEUROLOGY, 2014, 21 (01) : 57 - 64
  • [2] Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice
    He Xiao-li
    Zhao Shi-hui
    You Wei
    Cai Yu-ying
    Wang Yan-yun
    Ye Yong-ming
    Jia Bao-hui
    CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2018, 24 (02) : 133 - 139
  • [3] Serum brain-derived neurotrophic factor levels as a predictor for Alzheimer disease progression
    Tsai, Meng-Ju
    Lin, Yung-Shuan
    Chen, Chun-Yu
    Lee, Wei-Ju
    Fuh, Jong-Ling
    JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 2023, 86 (11) : 960 - 965
  • [4] Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases
    Ventriglia, Mariacarla
    Zanardini, Roberta
    Bonomini, Cristina
    Zanetti, Orazio
    Volpe, Daniele
    Pasqualetti, Patrizio
    Gennarelli, Massimo
    Bocchio-Chiavetto, Luisella
    BIOMED RESEARCH INTERNATIONAL, 2013, 2013
  • [5] Exercise enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic alterations in senescence-accelerated mice prone 8
    Li, Xiang
    Inoue, Takahiro
    Hayashi, Masataka
    Maejima, Hiroshi
    NEUROSCIENCE LETTERS, 2019, 706 : 176 - 181
  • [6] Levels of serum brain-derived neurotrophic factor in primates
    Takuma Mori
    Keiko Shimizu
    Motoharu Hayashi
    Primates, 2003, 44 : 167 - 169
  • [7] Levels of serum brain-derived neurotrophic factor in primates
    Mori, T
    Shimizu, K
    Hayashi, M
    PRIMATES, 2003, 44 (02) : 167 - 169
  • [8] Effects of Sesaminol Feeding on Brain Aβ Accumulation in a Senescence-Accelerated Mouse-Prone 8
    Katayama, Shigeru
    Sugiyama, Haruka
    Kushimoto, Shoko
    Uchiyama, Yusuke
    Hirano, Masato
    Nakamura, Soichiro
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016, 64 (24) : 4908 - 4913
  • [9] Serum brain-derived neurotrophic factor, nerve growth factor and neurotrophin-3 levels in dementia
    Konukoglu, Dildar
    Andican, Gulnur
    Firtina, Sinem
    Erkol, Gokhan
    Kurt, Asuman
    ACTA NEUROLOGICA BELGICA, 2012, 112 (03) : 255 - 260
  • [10] Identification of functional tRNA-derived fragments in senescence-accelerated mouse prone 8 brain
    Zhang, Shuai
    Li, Hejian
    Zheng, Ling
    Li, Hong
    Feng, Chengqiang
    Zhang, Wensheng
    AGING-US, 2019, 11 (22): : 10485 - 10498
12345