Stereotactic and fractionated stereotactic radiosurgery for single and multiple brain metastases: Results of multicenter planning studies

Purpose: Stereotactic and fractionated stereotactic radiosurgery (SRS/fSRS) utilization is growing in India, although planning studies are scarce. This study assessed clinical practices for SRS/fSRS treatment planning for brain metastases (BM) using ICRU-91 and explored the impact of planning tools. Methods & materials: Participants from 23 centers received two anonymized CT datasets with predrawn structures for single met (SM) and four BMs (MM) cases via email. Centers used local protocol to create plans. The plans were evaluated for target coverage, normal brain doses, and ICRU-91 dosimetric indices. Results: Monaco TPS overestimated mean GTV (PTV) by 3.7 (4.2)% and 2.1 (2.0)% for SM and MM respectively. Some institutions had good conformity and target coverage, whereas others had high OAR doses despite inadequate PTV dose coverage. Conformity index (CI) ranged from 1.07 to 1.45 (SM) and 1.06 to 1.25 (MM), and homogeneity index (HI) ranged from 0.07 to 0.28 (SM) and 0.13 to 0.32 (MM). Significant variation in GI and dose prescription isodose line selection was observed among centers. Conclusions: There was a significant heterogeneity in the planning parameters noted among different centers. The study emphasized the importance of established planning protocols and comprehensive training for staff involved in SRS/fSRS. Notably, plans with finer MLC width outperformed, yet wider MLC plans achieved ICRU91 indices comparable to published literature. The importance of our study is underscored by the absence of a national framework for SRS planning in India.