Biological roles and molecular mechanism of circular RNAs in epithelial-mesenchymal transition of gastrointestinal malignancies

被引：0

作者：

Fang, Ziyi ^{[1
,2
]}

Shao, Yongfu ^{[1
,2
]}

Hu, Meng ^{[1
]}

Yan, Jianing ^{[2
]}

Ye, Guoliang ^{[2
]}

机构：

[1] Ningbo Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ningbo 315211, Peoples R China

[2] Ningbo Univ, Affiliated Hosp 1, Dept Gastroenterol, Ningbo 315020, Peoples R China

来源：

ONCOLOGY RESEARCH | 2025年 / 33卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Epithelial-mesenchymal transition; Circular RNAs (circRNAs); Gastrointestinal malignancies; GASTRIC-CANCER CELLS; REPRESSES E-CADHERIN; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; TUMOR MICROENVIRONMENT; TRANSCRIPTION FACTOR; COLON-CANCER; EMT; METASTASIS; PROGRESSION;

D O I：

10.32604/or.2024.051589

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNAs (circRNAs) are formed by splicing of precursor RNAs and covalently linked at the 5 ' and 3 ' ends. Dysregulated circRNAs are closely related to the epithelial-mesenchymal transition (EMT) of gastrointestinal malignancies. CircRNAs, including circRNA_0008717, circGOT1, circ-DOCK5, circVPS33B, circPVT1, circMET, circOXCT1, circ_67835, circRTN4, circ_0087502, circFNDC38, circ_PTEN1, circPGPEP1, and circ-E-Cad are involved in the EMT process of gastrointestinal malignancies through a variety of mechanisms, such as regulating EMT-inducing transcription factors, signaling pathways, and tumor microenvironments. Gastrointestinal (GI) malignancies are common malignant tumors worldwide, and the heterogeneity and easy metastasis of gastrointestinal malignancies limit the effectiveness of medical treatments. Therefore, investigating the molecular mechanisms involved in the pathogenesis of gastrointestinal malignancies is essential for clinical treatment. This article summarizes the biological roles and molecular mechanism of circRNAs in EMT of gastrointestinal malignancies, providing a theoretical basis for applying EMT-related circRNAs in targeted therapy.

引用

页码：549 / 566

页数：18

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