The mystique of epigenetic regulation: the remarkable case of a human noncoding RNA, nc886

被引：0

作者：

Lee, Yeon-Su ^{[1
]}

Lee, Yong Sun ^{[2
]}

机构：

[1] Natl Canc Ctr, Res Inst, Rare Canc Branch, Goyang 10408, South Korea

[2] Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Biomed Sci, Goyang 10408, South Korea

来源：

EPIGENOMICS | 2024年 / 16卷 / 21-22期

关键词：

CpG methylation; disease; epigenetics; nc886; regulation; VTRNA2-1; DNA METHYLATION; PKR; KINASE; CANCER; TRANSCRIPTION; DISEASE; BREAST;

D O I：

10.1080/17501911.2024.2415278

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

nc886 is a regulatory noncoding RNA that is transcribed by RNA polymerase III (Pol III), is variably expressed in different biological contexts, and plays roles in inflammation and cancer. Epigenetic mechanisms play an intriguing role in regulating nc886 expression. As a maternally imprinted gene and metastable epiallele, nc866 exhibits polymorphic imprinting, with a methylation status that is influenced by environmental and biological factors. Consequently, the promoter DNA methylation status and the different resulting RNA expression levels of nc886 are associated with physiological and pathological conditions. In this review, we summarize the literature and explore the significance in relation to diverse roles of nc886.

引用

页码：1389 / 1405

页数：17

共 41 条

[31] Methylation Modification, Alternative Splicing, and Noncoding RNA Play a Role in Cancer Metastasis through Epigenetic Regulation [J].

Yu, Bin ;

Yu, Xin ;

Xiong, Jianping ;

Ma, Mei .

BIOMED RESEARCH INTERNATIONAL, 2021, 2021

[32] Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473 [J].

Khanh-Van Tran ;

Brown, Erin L. ;

DeSouza, Tiffany ;

Jespersen, Naja Zenius ;

Nandrup-Bus, Cecilie ;

Yang, Qin ;

Yang, Zinger ;

Desai, Anand ;

Min, So Yun ;

Rojas-Rodriguez, Raziel ;

Lundh, Morten ;

Feizi, Amir ;

Willenbrock, Hanni ;

Larsen, Therese Juhlin ;

Severinsen, Mai Charlotte Krogh ;

Malka, Kimberly ;

Mozzicato, Anthony M. ;

Deshmukh, Atul S. ;

Emanuelli, Brice ;

Pedersen, Bente Klarlund ;

Fitzgibbons, Timothy ;

Scheele, Camilla ;

Corvera, Silvia ;

Nielsen, Soren .

NATURE METABOLISM, 2020, 2 (05) :397-412

[33] Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice [J].

Spadaro, Paola A. ;

Flavell, Charlotte R. ;

Widagdo, Jocelyn ;

Ratnu, Vikram S. ;

Troup, Michael ;

Ragan, Chikako ;

Mattick, John S. ;

Bredy, Timothy W. .

BIOLOGICAL PSYCHIATRY, 2015, 78 (12) :848-859

[34] The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter [J].

Chao, Ti-Chun ;

Zhang, Qiong ;

Li, Zhonghan ;

Tiwari, Shashi Kant ;

Qin, Yue ;

Yau, Edwin ;

Sanchez, Ana ;

Singh, Gatikrushna ;

Chang, Kungyen ;

Kaul, Marcus ;

Karris, Maile Ann Young ;

Rana, Tariq M. .

MBIO, 2019, 10 (05)

[35] Long noncoding RNA-mediated epigenetic regulation of auxin-related genes controls shade avoidance syndrome in Arabidopsis [J].

Mammarella, Maria Florencia ;

Lucero, Leandro ;

Hussain, Nosheen ;

Munoz-Lopez, Aitor ;

Huang, Ying ;

Ferrero, Lucia ;

Fernandez-Milmanda, Guadalupe L. ;

Manavella, Pablo ;

Benhamed, Moussa ;

Crespi, Martin ;

Ballare, Carlos L. ;

Marcos, Jose Gutierrez ;

Cubas, Pilar ;

Ariel, Federico .

EMBO JOURNAL, 2023, 42 (24)

[36] Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA Lnc-Rewind in muscle stem cells [J].

Cipriano, Andrea ;

Macino, Martina ;

Buonaiuto, Giulia ;

Santini, Tiziana ;

Biferali, Beatrice ;

Peruzzi, Giovanna ;

Colantoni, Alessio ;

Mozzetta, Chiara ;

Ballarino, Monica .

ELIFE, 2021, 10

[37] Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA [J].

Khyzha, Nadiya ;

Khor, Melvin ;

DiStefano, Peter V. ;

Wang, Liangxi ;

Matic, Ljubica ;

Hedin, Ulf ;

Wilson, Michael D. ;

Maegdefessel, Lars ;

Fish, Jason E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (33) :16410-16419

[38] The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans [J].

Peschansky, Veronica J. ;

Pastori, Chiara ;

Zeier, Zane ;

Wentzel, Katya ;

Velmeshev, Dmitry ;

Magistri, Marco ;

Silva, Jose P. ;

Wahlestedt, Claes .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2016, 74 :49-57

[39] Deep RNA Sequencing Reveals Dynamic Regulation of Myocardial Noncoding RNAs in Failing Human Heart and Remodeling With Mechanical Circulatory Support [J].

Yang, Kai-Chien ;

Yamada, Kathryn A. ;

Patel, Akshar Y. ;

Topkara, Veli K. ;

George, Isaac ;

Cheema, Faisal H. ;

Ewald, Gregory A. ;

Mann, Douglas L. ;

Nerbonne, Jeanne M. .

CIRCULATION, 2014, 129 (09) :1009-1021

[40] Epigenetic Regulation of Tumor Necrosis Factor α (TNFα) Release in Human Macrophages by HIV-1 Single-stranded RNA (ssRNA) Is Dependent on TLR8 Signaling [J].

Han, Xinbing ;

Li, Xin ;

Yue, Simon C. ;

Anandaiah, Asha ;

Hashem, Falah ;

Reinach, Peter S. ;

Koziel, Henry ;

Tachado, Souvenir D. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (17) :13778-13786

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