The mystique of epigenetic regulation: the remarkable case of a human noncoding RNA, nc886

被引：0

作者：

Lee, Yeon-Su ^{[1
]}

Lee, Yong Sun ^{[2
]}

机构：

[1] Natl Canc Ctr, Res Inst, Rare Canc Branch, Goyang 10408, South Korea

[2] Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Biomed Sci, Goyang 10408, South Korea

来源：

EPIGENOMICS | 2024年 / 16卷 / 21-22期

关键词：

CpG methylation; disease; epigenetics; nc886; regulation; VTRNA2-1; DNA METHYLATION; PKR; KINASE; CANCER; TRANSCRIPTION; DISEASE; BREAST;

D O I：

10.1080/17501911.2024.2415278

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

nc886 is a regulatory noncoding RNA that is transcribed by RNA polymerase III (Pol III), is variably expressed in different biological contexts, and plays roles in inflammation and cancer. Epigenetic mechanisms play an intriguing role in regulating nc886 expression. As a maternally imprinted gene and metastable epiallele, nc866 exhibits polymorphic imprinting, with a methylation status that is influenced by environmental and biological factors. Consequently, the promoter DNA methylation status and the different resulting RNA expression levels of nc886 are associated with physiological and pathological conditions. In this review, we summarize the literature and explore the significance in relation to diverse roles of nc886.

引用

页码：1389 / 1405

页数：17

共 41 条

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