Colon cancer biology and treatment in the era of precision oncology: A primer for Radiologists

被引：0

作者：

Platt, James R. ^{[1
]}

Pennycook, Stephanie ^{[2
]}

Muthoo, Chand E. ^{[3
]}

Westwood, Alice C. ^{[4
]}

Frood, Russell ^{[5
]}

Beggs, Andrew D. ^{[6
]}

Scarsbrook, Andrew ^{[7
]}

Seligmann, Jenny F. ^{[1
]}

Tolan, Damian J. M. ^{[3
]}

机构：

[1] Univ Leeds, Leeds Inst Med Res St Jamess, Sch Med, Div Oncol, Leeds, England

[2] Leeds Teaching Hosp NHS Trust, Dept Med Oncol, Leeds, England

[3] Leeds Teaching Hosp NHS Trust, Dept Radiol, Leeds, England

[4] Univ Leeds, Leeds Inst Med Res St Jamess, Sch Med, Div Pathol & Data Analyt, Leeds, England

[5] Univ Leeds, Leeds Inst Clin Trials Res, Sch Med, Leeds, England

[6] Univ Birmingham, Dept Canc & Genom, Birmingham, England

[7] Univ Leeds, Leeds Inst Med Res St Jamess, Sch Med, Leeds, England

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 2025年 / 185卷

关键词：

Colon cancer; Systemic therapy; Chemotherapy; Immunotherapy; Radiology; Computed tomography; METASTATIC COLORECTAL-CANCER; MISMATCH REPAIR; IRINOTECAN; BEVACIZUMAB; FLUOROURACIL; CHEMOTHERAPY; RADIOMICS; CETUXIMAB; MULTICENTER; OXALIPLATIN;

D O I：

10.1016/j.ejrad.2025.112000

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In the era of precision oncology, systemic therapies for colon cancer are becoming increasingly biomarker-led, with implications for patients in the neoadjuvant, adjuvant and metastatic settings. As the landscape for colon cancer treatment evolves and becomes more complex, it is important that all members of the multidisciplinary team keep abreast of developments to ensure the most effective care is delivered to patients. As core members of the colorectal multidisciplinary team, Radiologists play a central role throughout the patient journey. This review serves as an educational summary of current and emerging treatment pathways in colon cancer, standards for biomarker testing, mechanisms of action for key drugs, important treatment-related complications, relevant tumour biology that underpins patterns of disease and treatment response, and the specific implications systemic therapies have for cancer imaging and Radiologists. We also highlight the increasing role for radiology in patient stratification and the importance of imaging biomarkers. It is crucial that Radiologists understand the current landscape of colon cancer treatment and emerging strategies on the horizon in clinical trials. Only through engagement across the wider multidisciplinary team will we deliver true personalised medicine for patients with colon cancer.

引用

页数：12

共 84 条

[1] Obaro A.E., Burling D.N., Plumb A.A., Colon cancer screening with CT colonography: logistics, cost-effectiveness, efficiency and progress, Br J Radiol, 91, 1090, (2018)
[2] Dizdarevic S.
[3] Herbertson R.A., Et al., Established, emerging and future roles of PET/CT in the management of colorectal cancer, Clin Radiol, 64, 3, pp. 225-237, (2009)
[4] Taylor S.A., Et al., Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial, Lancet Gastroenterol Hepatol, 4, 7, pp. 529-537, (2019)
[5] Tong G.J., Et al., Comparison of the eighth version of the American Joint Committee on Cancer manual to the seventh version for colorectal cancer: A retrospective review of our data, World J Clin Oncol, 9, 7, pp. 148-161, (2018)
[6] Argiles G., Et al., Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Ann Oncol, 31, 10, pp. 1291-1305, (2020)
[7] Lord A.C., Et al., Significance of extranodal tumour deposits in colorectal cancer: A systematic review and meta-analysis, Eur J Cancer, 82, pp. 92-102, (2017)
[8] Morton D., Et al., Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial, J Clin Oncol, 41, 8, pp. 1541-1552, (2023)
[9] Cervantes A., Et al., Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up, Ann Oncol, 34, 1, pp. 10-32, (2023)
[10] Taieb J., Andre T., Auclin E., Refining adjuvant therapy for non-metastatic colon cancer, new standards and perspectives, Cancer Treat Rev, 75, pp. 1-11, (2019)

← 1 2 3 4 5 6 7 8 9 →