Systemic fluoride levels in toenails as biomarkers of exposure and their association with the severity of dental fluorosis in Mexican schoolchildren - a cross-sectional study

被引:0
作者
Lavalle-Carrasco, Jesus [1 ]
Molina-Frechero, Nelly [2 ]
Hernandez-Perez, Elizabeth [3 ]
Sanchez-Perez, Leonor [2 ]
Lopez-Verdin, Sandra [4 ]
Bologna-Molina, Ronell [5 ,6 ]
机构
[1] Autonomous Metropolitan Univ UAM, Biol & Hlth Sci Ph D Program, Mexico City, Mexico
[2] Autonomous Metropolitan Univ Xochimilco UAM X, Dept Hlth Care, Div Biol & Hlth Sci, Mexico City, Mexico
[3] Autonomous Metropolitan Univ Iztapalapa UAM I, Dept Hlth Sci, Div Biol & Hlth Sci, Mexico City, Mexico
[4] Univ Guadalajara UdG, Hlth Sci Univ Ctr, Inst Dent Res, Guadalajara, Mexico
[5] Univ Republ UDELAR, Fac Dent, Mol Pathol Area, Montevideo, Uruguay
[6] Juarez Univ Durango State UJED, Fac Dent, Dept Res, Victoria De Durango, Mexico
关键词
Fluoride; nails; dental fluorosis severity; biomarkers; schoolchildren; FINGERNAIL FLUORIDE; DRINKING-WATER; CONTAMINATION; GROUNDWATER; CHILDREN; RISK;
D O I
10.1080/1354750X.2025.2456657
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Introduction Elevated fluoride (F-) exposure during childhood produces dental fluorosis (DF). Nails have been used for monitoring systemic F- in relation to DF. The aim of this study was to evaluate F- levels in toenails in association with DF severity in Mexican schoolchildren. Materials and methods 120 schoolchildren from nonendemic areas (NEAs) and endemic F- areas (EAs) were screened for DF via the Thylstrup and Fejerskov index (TFI). Toenails were collected to quantify systemic F-. The associations between the biomarker, DF severity, tap water intake, sex, and age were analyzed. Results The mean F- in toenails in the NEAs and EAs were 0.63 +/- 0.43 and 2.72 +/- 1.38 mg/kg, respectively (p < 0.001). A positive correlation was observed between the biomarker and DF severity (r(s) = 0.755, p < 0.001). Tap water consumption and the biomarker were associated with DF severity (p < 0.001). Within TFI7-8 the mean F- level was higher in those ages 10-11 than in those ages 8-9 (p < 0.05). Conclusion Systemic F- levels in toenails are associated with DF severity in Mexican schoolchildren from both the NEAs and the EAs, which reflects the ability of the biomarker to accurately record the exposure to the compound in relation to clinical damage.
引用
收藏
页码:140 / 146
页数:7
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