Dissolving microneedles for brain delivery: Recent advances and challenges

被引：1

作者：

Kolekar, Kaustubh Ajit ^{[1
]}

Kumbhar, Popat S. ^{[2
]}

Vishwas, Sukriti ^{[1
]}

Dua, Kamal ^{[3
,4
]}

Singh, Sachin Kumar ^{[1
,5
]}

机构：

[1] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[2] Tatyasaheb Kore Coll Pharm, Dept Pharmaceut, Kolhapur 416113, Maharashtra, India

[3] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia

[4] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia

[5] Sunway Univ, Sunway Biofunct Mol Discovery Ctr SBMDC, Sch Med & Life Sci, Bandar Sunway 47500, Malaysia

来源：

DRUG DISCOVERY TODAY | 2025年 / 30卷 / 04期

关键词：

dissolving microneedles; brain delivery; minimally invasive devices; neurodegenerative diseases; TRANSDERMAL DRUG-DELIVERY; DESIGN;

D O I：

10.1016/j.drudis.2025.104330

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past decade, dissolving microneedles (DMNs) have emerged as a promising approach for drug delivery to the brain. They are tiny devices designed to penetrate biological barriers, offering a painless method for localized and controlled drug delivery. They are suitable for delivering drugs that are susceptible to degradation when delivered orally. Recently, drug-loaded DMNs have been explored for treating neurodegenerative diseases, including Alzheimer's (AD) and Parkinson's disease (PD). DMNs can deliver drugs efficiently to the brain via the intranasal, transdermal, and intracranial routes. In this review, we discuss the use of DMNs for delivering drugs to the brain, recent technological advances, clinical status, and current challenges related to their translation.

引用

页数：10

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