Structural properties and sustained antimicrobial activity of thymol-loaded cellulose nanofibers from one-pot synthesis via in situ dynamic microfluidization

被引：0

作者：

Wanmolee, Wanwitoo ^{[1
,2
]}

Kraithong, Wasawat ^{[3
]}

Phanthasri, Jakkapop ^{[3
]}

Pipattanaporn, Pornnapa ^{[3
]}

Samun, Yodsagon ^{[4
]}

Youngjan, Saran ^{[3
]}

Yodsin, Nuttapon ^{[5
]}

Saengsrichan, Aphinan ^{[6
]}

Treetong, Alongkot ^{[3
]}

Phawa, Chaiyasit ^{[3
]}

Pakawanit, Phakkhananan ^{[7
]}

Fuangnawakij, Kajornsak ^{[3
]}

Laurenti, Dorothee ^{[8
]}

Geantet, Christophe ^{[8
]}

Sakdaronnarong, Chularat ^{[9
]}

Khemthong, Pongtanawat ^{[3
]}

Sukrong, Suchada ^{[4
]}

机构：

[1] King Mongkuts Univ Technol North Bangkok KMUTNB, Fac Engn, Dept Chem Engn, Bangkok 10800, Thailand

[2] King Mongkuts Univ Technol North Bangkok, Ctr Ecomat & Cleaner Technol, Bangkok 10800, Thailand

[3] Natl Sci & Technol Dev Agcy NSTDA, Natl Nanotechnol Ctr NANOTEC, Pathum Thani 12120, Thailand

[4] Chulalongkorn Univ, Fac Pharmaceut Sci, Ctr Excellence DNA Barcoding Thai Med Plants, Dept Pharmacognosy & Pharmaceut Bot, Bangkok 103300, Thailand

[5] Silpakorn Univ, Fac Sci, Dept Chem, Nakhon Pathom 73000, Thailand

[6] Chulalongkorn Univ, Grad Sch, Int Program Hazardous Subst & Environm Management, Bangkok 10330, Thailand

[7] Synchrotron Light Res Inst Publ Org, Synchrotron Res & Applicat Div, Nakhon Ratchasima 30000, Thailand

[8] Univ Claude Bernard Lyon 1, CNRS, UMR 5256, Inst Rech Catalyse & Environm Lyon IRCELYON, 2 Ave Albert Einstein, F-69626 Villeurbanne, France

[9] Mahidol Univ, Fac Engn, Dept Chem Engn, 25-25 Putthamonthon 4 Rd, Nakhon Pathom 73170, Thailand

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2025年 / 306卷

关键词：

Cellulose nanofibers (CNFs); Thymol; Dynamic high-pressure microfluidization; Slow-release; Antibacterial activity; ANTIBACTERIAL; IMPREGNATION; FIBERS;

D O I：

10.1016/j.ijbiomac.2025.141712

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physicochemical properties of cellulose nanofibers (CNFs) are significantly influenced by their production methods and surface modifications. This study presents an eco-friendly approach for synthesizing CNFs impregnated with thymol via a single-step in-situ dynamic high-pressure microfluidization process. Optimal conditions for preserving the intrinsic structure and desirable properties of CNFs were explored using various ethanol-water ratios with thymol. The physicochemical properties and characteristics of CNFs were analyzed using advanced techniques. Thymol-impregnated CNFs at an ethanol-to-water ratio of 10:90 (E10W90) demonstrated a sustained cumulative release of up to 27.5 % over 50 h and complete inhibition of bacterial growth within 3 h against S. aureus and E. coli. Density functional theory analysis indicated that thymol adsorption onto the CNF surface is facilitated by hydrogen bonding. This investigation proposes a novel, energyefficient method for thymol impregnation, achieving prolonged antimicrobial activity without complex surface modifications.

引用

页数：15

共 70 条

[31] Application of enzyme-mediated cellulose nanofibers from lemongrass waste for the controlled release of anticancer drugs [J].