Relationship Between Red Blood Cell Indices and Myxomatous Mitral Valve Disease in Small-Breed Dogs: A Retrospective Study

被引：0
作者：
Hong, Eui-Joo [1 ,2 ]
Jeong, Yunho [1 ,2 ]
An, Ju-Hyun [3 ]
Choi, Sooyoung [4 ]
Chung, Jin-Young [1 ,2 ]
Ahn, Jin-Ok [1 ,2 ]
机构：
[1] Kangwon Natl Univ, Dept Vet Internal Med, Chunchon, South Korea
[2] Kangwon Natl Univ, Inst Vet Sci, Coll Vet Med, Chunchon, South Korea
[3] Kangwon Natl Univ, Coll Vet Med, Dept Vet Emergency & Crit Care Med, Chunchon, South Korea
[4] Kangwon Natl Univ, Coll Vet Med, Dept Vet Diag Imaging, Chunchon, South Korea
来源：
VETERINARY MEDICINE AND SCIENCE | 2025年 / 11卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
blood cell count; dogs; echocardiography; erythrocyte indices; mitral valve disease; DISTRIBUTION WIDTH; IRON-DEFICIENCY; HEART-FAILURE; PATHOPHYSIOLOGY; PARAMETERS; ETIOLOGY; ANEMIA;
D O I：
10.1002/vms3.70284
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Background: Red blood cell (RBC) indices provide information on the size and haemoglobin content of erythrocytes. The RBC distribution width (RDW) is an index of size variability of the circulating RBC population. The correlation between various diseases and RDW in dogs has been demonstrated. Some studies have evaluated RDW in dogs with myxomatous mitral valve disease (MMVD), and conflicting results have been reported. Objectives: We aimed to evaluate the association between RBC indices, complete blood cell counts (CBC), and serum biochemical and echocardiographic variables in small-breed dogs with MMVD. Methods: RBC indices, CBC, and serum biochemical and echocardiographic variables were retrospectively investigated in 102 client-owned dogs with MMVD at various disease stages. Results: RBC indices were not statistically significant among groups (control group, compensated group, decompensated group). RDW had a significant positive correlation with haematocrit (Hct) (correlation coefficient, 0.452) and a negative correlation with MCH (correlation coefficient, -0.498) and MCV (correlation coefficient, -0.357). The end-diastolic volume index, fractional shortening (%), and left atrial-anteroposterior diameter normalised for body weight were echocardiographic variables that affected MMVD severity. Conclusions: We observed no correlation between RBC indices and MMVD. However, conflicting results have been reported in several other studies; thus, further studies should be considered.
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页数：7
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共 28 条
  • [21] Oh J., Kang S., Hong N., Et al., Relation Between Red Cell Distribution Width With Echocardiographic Parameters in Patients With Acute Heart Failure, Journal of Cardiac Failure, 15, 6, pp. 517-522, (2009)
  • [22] Pfeifer M.E., Prittie J.E., Zollo A.M., Weltman J.G., Red Cell Distribution Width, Illness Severity, and All-Cause Mortality in Dogs Admitted to the ICU, Journal of Veterinary Emergency and Critical Care, 32, 2, pp. 168-172, (2022)
  • [23] Rangaswami J., Bhalla V., Blair J.E.A., Et al., Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association, Circulation, 139, 16, pp. e840-e878, (2019)
  • [24] Ronco C., Haapio M., House A.A., Anavekar N., Bellomo R., Cardiorenal Syndrome, Journal of the American College of Cardiology, 52, 19, pp. 1527-1539, (2008)
  • [25] Salvagno G.L., Sanchis-Gomar F., Picanza A., Lippi G., Red Blood Cell Distribution Width: A Simple Parameter With Multiple Clinical Applications, Critical Reviews in Clinical Laboratory Sciences, 52, 2, pp. 86-105, (2015)
  • [26] Savarese A., Probo M., Locatelli C., Et al., Iron Status in Dogs With Myxomatous Mitral Valve Disease, Polish Journal of Veterinary Sciences, 21, 3, pp. 507-515, (2018)
  • [27] Tang Y., Katz S.D., Anemia in Chronic Heart Failure: Prevalence, Etiology, Clinical Correlates, and Treatment Options, Circulation, 113, 20, pp. 2454-2461, (2006)
  • [28] Valenciano A.C., Cowell R.L., Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat-E-Book, (2019)
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