The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

被引：0
作者：
Wu, Yongmei [1 ]
Song, Wenqian [1 ]
Su, Min [1 ,2 ]
He, Jing [3 ]
Hu, Rong [1 ,3 ]
Zhao, Youbo [1 ,2 ]
机构：
[1] Guizhou Med Univ, Dept Human Histol & Embryol, Guiyang, Guizhou, Peoples R China
[2] Guizhou Med Univ, Ctr Tissue Engn & Stem Cell Res, Key Lab regenerat Med Guizhou Prov, Guiyang, Guizhou, Peoples R China
[3] Guizhou Med Univ, Characterist Key Lab Translat Med Res Cardiovasc &, Guiyang, Guizhou, Peoples R China
来源：
CANCER MEDICINE | 2025年 / 14卷 / 07期
关键词：
cancer; cholesterol; immune; metabolism; tumor microenvironment; PICK C1-LIKE 1; HMG-COA REDUCTASE; PROSTATE-CANCER; HEPATOCELLULAR-CARCINOMA; DIETARY-CHOLESTEROL; SQUALENE EPOXIDASE; LIPID-METABOLISM; GENE-EXPRESSION; DENDRITIC CELLS; NPC1L1; PROTEIN;
D O I：
10.1002/cam4.70783
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently promoting tumorigenesis. These biological changes involve modifications in numerous enzymes associated with cholesterol uptake and synthesis, including NPC1L1, SREBP, HMGCR, SQLE, and PCSK9. Review: This review systematically summarizes the role of cholesterol metabolism and its associated enzymes in cancer progression, examines the mechanisms through which dysregulation of cholesterol metabolism affects immune cells within the tumor microenvironment, and discusses recent advancements in cancer therapies that target cholesterol metabolism. Conclusion: Targeting cholesterol metabolism-related enzymes can inhibit tumor growth, reshape immune landscapes, and rejuvenate antitumor immunity, offering potential therapeutic avenues in cancer treatment.
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页数：27
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