Therapeutic Effect of Mesenchymal Stem Cells and Olive Leaf Extract Against Cytotoxicity Induced by Streptozotocin in Gestational Diabetes Rats

被引:0
|
作者
Abdrabou, Mervat Ahmed [1 ]
Atwa, Ahmed [2 ]
Massoud, Diaa [1 ]
Asran, Aml M. [3 ]
Alrayes, Zahrah R. [1 ]
Al-Otaibi, Aljohara M. [4 ]
Alghamdi, Fawzyah A. [5 ]
Germoush, Mousa [1 ]
Alruwaili, Hadeel K. [1 ]
Nabeeh, Ahmed [2 ]
Mehany, Ahmed B. M. [2 ]
机构
[1] Jouf Univ, Coll Sci, Olive Res Ctr, Biol Dept, POB 2014, Sakaka, Saudi Arabia
[2] Al Azhar Univ, Fac Sci, Zool Dept, Cairo 11884, Egypt
[3] Jouf Univ, El Jouf Univ, Olive Res Ctr, Sakaka, Saudi Arabia
[4] Princess Nourah bint Abdulrahman Univ, Coll Sci, Dept Biol, Riyadh 13225, Saudi Arabia
[5] Univ Jeddah, Coll Sci, Dept Biol Sci, POB 80327, Jeddah 21589, Saudi Arabia
关键词
Gestational Type 2 Diabetes; Streptozotocin; Mesenchymal Stem Cells; Olive leaves; DIABETOGENIC ACTION; BONE-MARROW; MELLITUS; ANTIOXIDANT; ALPHA; IMPROVES; OBESITY; KIDNEY; INJURY; MOUSE;
D O I
10.33594/000000744
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Background/Aims: Gestational Diabetes Mellitus (GDM), a prevalent complication in pregnancy, is characterized by the Diabetes Association as diabetes diagnosed in the second or third trimester, often remaining asymptomatic. This study investigates the intricate effects of Streptozotocin on pregnant rats, unraveling its impact on Gestational Type 2 Diabetes (GTD). The research delves into the potential therapeutic roles of mesenchymal stem cells (MSCs) and olive leaf extract (OLE) in mitigating the consequences of Streptozotocin-induced pancreatic impairment. Methods: Female rats were divided into control group, diabetic group, group treated with stem cells after diabetes, group treated with olive leaf extract after diabetes, and group treated with olive leaf extract and stem cells after diabetes. A comprehensive analysis was conducted for all study groups, including diabetic patients' files, hormonal dynamics, histopathological changes, tissue immune responses, and antioxidant mechanisms for all study groups. Results: The results of the study showed that diabetes causes changes in the level of insulin, HB A1C, Fructosamine, HOMA-IR and hormones compared to control group. On the contrary, there was a noticeable improvement in these parameters after treatment with olive leaf extract and stem cells. The results of the present study demonstrated that the combination of OLE and MSCs emerges as a promising approach, demonstrating enhanced glycemic control, modulation of insulin resistance, and improvements in pancreatic islet health. Aso, histopathological results underscore positive effects on pancreatic islet integrity. Conclusion: Stem Cells and Olive Leaf Extract demonstrate favorable effects on regenerative pancreatic cells under normal conditions.
引用
收藏
页码:702 / 721
页数:20
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