Magnetic hyperthermia mediated multimodal therapy for tumors: Construction and potential applications of iron-based nanoplatforms

Due to the rapid advancement of magnetic particle imaging technology, research has identified a novel therapeutic approach that is anticipated to combat tumors with the advantages of precise treatment and real-time dynamic monitoring: a multimodal therapeutic platform for magnetothermal therapy-mediated tumor treatment (iron-based nanoplatform). Iron-based nanoplatforms, exhibiting outstanding features including magnetothermal properties, light absorption, nano-enzymatic-like activity, biosafety, and magnetic imaging capabilities, have been integrated with chemotherapy, radiotherapy, dynamic therapy, photothermal therapy, immunotherapy, and other multimodal synergistic therapies. With the intention of informing and assisting researchers from diverse backgrounds in maintaining currency with the latest developments in this field, this study provides a comprehensive overview of the progress in iron-based nanoplatforms for magnetothermal therapymediated multimodal treatment of tumors, including compositional adjustments, structural optimization, property analysis, clinical applications, and concludes with a discussion of the scientific challenges that must be addressed in the development of iron-based nanoplatforms.